Heart system

hs-CRP (high-sensitivity)

hs-CRP

A sensitive marker of systemic inflammation — and a cardiovascular risk indicator.

What is it

hs-CRP (high-sensitivity) — in plain English.

High-sensitivity C-reactive protein measures low-grade systemic inflammation. It is a more sensitive version of the standard CRP test, designed to detect lower levels relevant to cardiovascular research.

Why it's measured

What hs-CRP can reveal.

hs-CRP has been associated with cardiovascular risk in large epidemiologic studies and is included in some cardiovascular risk calculators.

Reference range

Where most laboratories draw the standard line.

Standard laboratory reference

< 1.0 mg/L

Reference ranges vary by laboratory. Your individual reference range will appear on your test report and should be interpreted by your physician in the context of your overall health profile.

What results may indicate

Higher vs. lower hs-CRP — at a high level.

Elevated

Values 1–3 mg/L (intermediate) and >3 mg/L (high) have been associated with elevated cardiovascular risk in research literature.

Lower

Is generally considered favorable.

These associations are general. They are not a personal diagnosis or prediction. Discuss your individual results with your physician in the context of your full health profile.

When it's measured

When hs-CRP is typically run.

Used in cardiovascular risk evaluation. Acute infection or injury can transiently elevate values.

Related markers

Often measured alongside hs-CRP.

Measured in

hs-CRP is one of 160 biomarkers in the Apex Panel.

A complete look at your heart, hormones, metabolism, inflammation, and longevity systems — drawn at Quest or LabCorp, reviewed by a U.S.-licensed physician.

Explore the Apex Panel
160 biomarkers13 body systemsPhysician-reviewed
Back to all biomarkers

This information is for general educational purposes only and is not medical advice. Lab results alone are not intended to diagnose, treat, or cure any condition and do not replace the advice of a healthcare provider. OPTML does not offer medical advice, a diagnosis, medical treatment, or any form of medical opinion.