The Protocol pairs compounded tirzepatide for medically-supervised weight loss with compounded sermorelin, a GHRH peptide that supports deeper sleep and physiological recovery. One physician-led plan for patients who want GH-axis support for sleep and recovery alongside their weight-loss protocol.
✓GLP-1 weight loss + GHRH sleep & recovery support
Prescription only★★★★★4.9 · 200,000+ patients across our provider network
The Protocol, explained
Lose weight. Sleep and recover.
The Protocol pairs two physician-prescribed compounded medications: tirzepatide (a dual GIP / GLP-1 receptor agonist used in physician-supervised weight-management protocols) and sermorelin (a growth-hormone-releasing peptide that supports sleep architecture and physiological recovery during age-related GH decline).
Tirzepatide supports medical weight loss; sermorelin supports the body's natural GH/IGF-1 axis, deeper sleep, and physiological recovery. A physician may pair them for patients who want sleep and recovery support during weight loss. Individual results vary.
Weight loss can be demanding on sleep and recovery. Sermorelin supports the body's own growth-hormone axis, which is most active during deep sleep.
Sermorelin stimulates your pituitary to release endogenous growth hormone in a natural, pulsatile pattern, most active during deep sleep — supporting sleep depth and physiological recovery.
The result is weight-loss support alongside GH-axis support for sleep and recovery. Individual results vary.
Adults pursuing medically-supervised weight loss who also want GH-axis support for sleep and recovery. The Protocol pairs a GLP-1 with GHRH support for a more comprehensive plan.
Your physician will confirm whether it fits you during intake. Individual results vary.
Tirzepatide: a dual GIP and GLP-1 receptor agonist. The literature describes the dual mechanism as having a stronger appetite-modulation profile than GLP-1 alone.
Sermorelin: Stimulates natural GH release; supported by 30+ years of clinical use for adult GH-axis support, sleep depth, and recovery. Walker RF et al, Endocrine, 2006; Khorram O et al, 1997.
Stack rationale: Sermorelin's GH-axis, sleep, and recovery support is documented in adults with age-related GH decline. Pairing it with GLP-1 weight loss is an emerging clinical pattern, not yet in any FDA-approved combination product — which is why we offer it as compounded.
Tirzepatide alone vs The Protocol
Tirz alone
1
medication
The Protocol
2
medications
What it optimizes
Appetite and intake
Appetite, intake and overnight repair
GH-axis support
No
Yes
Sleep quality
No effect
Deeper REM & slow-wave
Recovery
No effect
Faster
Monthly cost
$349/mo
$498/mo
Best for
Weight loss
Weight loss + recovery
Comparison reflects a single-medication vs two-medication protocol. Compounded preparations are not FDA-approved. Individual results vary; not a guarantee of outcome.
What you get
Everything in your Stack kit
Two physician-prescribed compounded medications, full supplies, and ongoing provider support. One $498/mo all-inclusive plan.
Compounded tirzepatide
Sterile multi-dose vials. Once-weekly. Your provider sets and adjusts the dose.
Compounded sermorelin
Daily subcutaneous, taken at night. Provider-dosed for endogenous GH support.
Sterile syringes & needles
Pre-paired insulin syringes for both medications.
Provider + care messaging
U.S.-licensed provider oversight on both medications. Ongoing clinical support.
Provider consult, compounded medication, syringes, and ongoing clinical support, all included.
Physician-directed care
A U.S.-licensed physician personally reviews every order before anything is prescribed.
U.S.-licensed physicians
Reviews every order
LegitScript Certified
503A pharmacy · USP <797>
The High-Performer Protocol
One flat price. Every dose.
Compounded tirzepatide + sermorelin, both physician-prescribed, both shipped together. Your monthly price stays the same regardless of tirzepatide dose tier — from 2.5 mg up to 15 mg.
Compounded tirzepatide vial
Compounded sermorelin vial
Ongoing clinical support
Free discreet shipping (one bundled kit)
Cancel anytime · HSA/FSA eligible
All-inclusive
$498/month— cancel anytime
Both medications, all supplies, all provider access — same price at every tirzepatide dose.
Your physician titrates both medications based on your response. Sleep quality is among the effects discussed in the clinical literature; individual results vary.
Your monthly price includes everything.
Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.
Your medication is not sitting on a shelf waiting for you. It is prepared for you,
to your prescription, after a physician has read your file — and that is the reason for the
wait. Here is where every day goes.
7–10 days
from ordering to it arriving, for a straightforward protocol.
Roughly 5–7 days for the physician and the pharmacy, then 2–3 days in transit.
Your online visitabout 10 minutes
Done from your kitchen table, not a waiting room. No appointment to book,
no clinic to drive to, no time off work. You answer questions about your health and your goals,
and that is the whole of your part in it.
A physician actually reads your filethe slow part, on purpose
A U.S.-licensed physician goes through what you submitted, and your lab work
where your protocol calls for it. This is a real clinical decision made by a real person, which is
why it takes days rather than minutes — and it is the step you would least want us to rush.
Some protocols need a further conversation, or bloodwork first. TRT, enclomiphene and HRT
commonly do.
Your medication is made for younot off a shelf
Once a physician approves it, your prescription goes to a state-licensed,
FDA-registered 503A compounding pharmacy, where it is prepared for you individually under
USP <797> sterility standards.
That is what compounding means: it is made to your prescription after it is written, rather
than manufactured in advance and picked from stock. It is also why this is measured in days.
Compounded preparations are not FDA-approved.
It ships to your door2–3 days
Insulated and temperature-controlled, in plain packaging with no medical
branding on the outside. Shipping is free and already in your price, and tracking is emailed
when it leaves.
The one thing that holds an order upworth reading
An order pauses if something is still outstanding on your side — an
intake form you have not finished, ID verification, or lab work. It is the most common reason an
order goes quiet, and the system cannot always alert you when it happens.
So if it has been quiet for a couple of days, check your email and your
patient portal before
anything else. That is nearly always where the missing piece is, and clearing it starts your order
moving again immediately. Full checklist here.
Ordering on a Friday or at the weekend
Orders are processed seven days a week. What is not covered at weekends is
anything needing a person — a stuck form, an ID check, a question for your provider. Order
late on a Friday and you will likely hear more at the start of the week.
How to check where you are
Your patient
portal shows the live stage of your order. If your purchase appears there and you have the
confirmation email, you are in the queue and nothing is wrong.
These are typical ranges, not guarantees, and delays do happen. Something look wrong?
Email info@optml.health and a person will pick it up.
For anything clinical, message your physician in the portal. For emergencies, call 911.
Stack FAQs
Sermorelin supports the body's natural GH/IGF-1 axis, sleep depth, and recovery, which is part of why a physician may pair the two during medical weight loss. Whether this approach fits you is determined by your physician. Compounded preparations are not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. Individual results vary.
Common (>10%): mild nausea (especially first 1-2 weeks of each new dose), decreased appetite, fatigue, constipation. Most resolve within 2-4 weeks; slower titration helps.
Less common (1-10%): diarrhea or vomiting, headache, dizziness, acid reflux, mild injection-site reaction. Tell your provider — dose adjustments usually fix these.
Rare (<1%): pancreatitis, gallbladder issues, severe allergic reaction, diabetic retinopathy worsening (in patients with diabetes).
Black-box / contraindicated: personal/family history of medullary thyroid carcinoma (MTC), MEN-2 syndrome, pregnancy, breastfeeding, severe gastroparesis.
OPTML's compounded tirzepatide is prepared by FDA-registered 503A pharmacies under USP <797> sterility standards, on prescription by a U.S. licensed physician. Compounded medications are not FDA-approved.
Sermorelin is a daily subcutaneous injection taken at night, typically right before bed on an empty stomach. The timing is intentional: GH release naturally peaks during deep sleep, so dosing then amplifies your body's own pulse rather than creating an unnatural one. Tirzepatide is a separate weekly injection.
No, and that's an important distinction. HGH (somatropin) replaces growth hormone directly. Sermorelin is a GHRH peptide that stimulates your pituitary to release your own growth hormone in its natural pulsatile pattern. That's why sermorelin has a far cleaner safety profile and is legal as a prescription compounded peptide while HGH is tightly restricted.
Sermorelin supports your body's own growth-hormone axis, which is most active during deep sleep and is involved in sleep quality and physiological recovery. Adequate protein and healthy activity support your results during a weight-loss phase. Individual results vary.
No — labs are an add-on. Both medications affect metabolic and hormone markers, so we strongly recommend running an OPTML lab panel (IGF-1, free testosterone, lipid panel, A1C) before starting and at regular intervals after. The panel is offered at member rates as an add-on, not bundled into the $498 monthly retail.
Yes. You can step down to tirzepatide alone or sermorelin alone at any time, or pause both. Just message your provider — no contracts, no commitment.
Flat $498/mo — both compounded medications, provider oversight via call or text, all syringes, needles, alcohol pads, sharps container, and shipping. Same retail at every dose tier. Lab panels are a separate add-on at member rates. Cancel anytime.
15 free tools
Learn more about hitting your goals
Free calculators and quizzes built around real clinical data. Use them as often as you want.
Tirzepatide and sermorelin are serious prescription medications with real contraindications. Read the full GLP-1 and sermorelin eligibility, side effects, and warnings before starting. The Protocol is not for use during pregnancy, breastfeeding, with active malignancy, or with personal/family history of medullary thyroid carcinoma or MEN-2.
Weight loss, with GH-axis support for sleep and recovery.
5-minute online consult. Physician review. Both medications ship together, free and discreet.
Your GLP-1 field guides — side-effect playbook and what to expect, week by week.
Free tools — daily protein target, TDEE, calorie math, and more.
Included free with your active High Performer protocol. No separate
membership, no add-on charges.
Weight-loss medication disclaimer
OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.
The complete GLP-1 guide
The whole picture in one sitting: who it suits, what the labs decide, what the first year actually looks like. Every clinical claim is cited.
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