Is sermorelin more effective than semaglutide?

Head-to-head trials (SURMOUNT-5) showed sermorelin produced roughly 50% more weight loss than semaglutide over 72 weeks. Sermorelin activates both GIP and GLP-1 receptors, while semaglutide only activates GLP-1, which likely explains the stronger effect.

What are the side effects?

Most common: nausea, constipation, diarrhea, fatigue, typically mild and temporary. Side effect profile is similar to semaglutide. Your provider starts you at a low dose and titrates up slowly.

Can I switch from semaglutide to sermorelin?

Yes. Many patients switch for stronger results or fewer GI side effects. Your OPTML provider will manage the transition and titration plan.

Do I need labs before starting?

Not always required, but strongly recommended. We offer an optional comprehensive metabolic panel to establish baseline markers before starting treatment.

GHRH peptide for sleep, recovery & lean mass

Compounded sermorelin,
prescribed online.

A growth-hormone-releasing peptide that signals your pituitary to release endogenous GH in its natural pulsatile pattern — most active during deep sleep. The result: improved sleep architecture, enhanced recovery, and support for lean-mass preservation during age-related growth hormone decline.

Deeper sleep + faster recovery
Lean-mass preservation during cuts
Free 2-3 day discreet shipping
Free provider consult · cancel anytime

Get started How it works →

Compounded medication is not FDA-approved. Starting at $189/mo · HSA/FSA eligible.

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Prescription only 4.9 · 200,000+ patients

Recovery · GHRH peptide

★★★★★4.9 / 200,000+ patients across our provider network

Sleep deeper. Recover faster. Protect muscle.

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Compounded sermorelin is a GHRH peptide that signals your pituitary to release your own growth hormone in its natural pulsatile pattern — most active during deep sleep. The result: improved sleep architecture, enhanced recovery, and support for lean-mass preservation during age-related growth hormone decline. Physician-prescribed and shipped monthly.

Deeper sleep + recovery
Lean-mass preservation
Endogenous GH support
Cancel anytime

Start your free assessment How it works

Starting at $189/mo · Free provider consult · HSA/FSA eligible

What to expect on sermorelin

A timeline grounded in clinical use.

Wk 1-2

Deeper sleep

Most patients report falling asleep faster and staying in slow-wave sleep longer within the first 7-14 nights.

Wk 3-6

Faster recovery

Soreness shortens, training quality lifts, joint and connective-tissue feel improves.

Wk 8-12

Body composition shifts

Lean mass holds or improves; visceral fat tends to decrease; IGF-1 markers often move toward optimal range.

Wk 12+

Sustained baseline lift

Sleep, recovery, and composition gains compound. Provider re-evaluates every 12 weeks.

Timeline reflects typical clinical experience and published GHRH peptide literature. Individual results vary.

Educational tool · GHRH support during weight loss

Clinically documented muscle loss on GLP-1s. See how GHRH support changes the math.

In STEP-1 and SURMOUNT-1, roughly 25-40% of total weight lost during GLP-1 therapy came from lean tissue — a clinically meaningful safety concern with implications for resting metabolic rate, sarcopenia risk, and long-term weight-loss maintenance. The educational illustration below models how GHRH-axis support during GLP-1 therapy may shift this composition.

8lbs

At 220 lbs on a 12-month GLP-1 protocol with GHRH support, an estimated ~8 lbs of lean tissue may be preserved compared with GLP-1 monotherapy.*

Current weight

220lbs

Estimated total weight lost

44lbs

Estimated lean tissue lost

13lbs

*Educational illustration only. Total weight-loss estimates reflect aggregate clinical-trial data from STEP-1 (semaglutide, Wegovy®) and SURMOUNT-1 (tirzepatide, Zepbound®), which studied FDA-approved branded products — not compounded preparations. Lean-tissue percentages reflect published GLP-1 body-composition literature; GHRH-support estimates reflect mechanism-based modeling, not head-to-head trial data. Compounded preparations are not FDA-approved; the FDA does not verify the safety, effectiveness, or quality of compounded drugs. Individual results vary. This tool is not medical advice, does not constitute a prescription, and is not a substitute for individual evaluation by a licensed physician.

Sermorelin, explained

Your own growth hormone, amplified.

Sermorelin is a GHRH (growth-hormone-releasing hormone) peptide. It signals your pituitary to release your own growth hormone in its natural pulsatile pattern — most active during deep sleep. It's a daily subcutaneous injection, taken at night before bed.

OPTML's compounded sermorelin is prepared by FDA-registered 503A pharmacies under USP <797> sterility standards, prescribed by U.S. licensed providers, and shipped to your door monthly.

No — and that's a critical distinction. HGH (somatropin) replaces growth hormone directly. Sermorelin is a GHRH peptide that stimulates your pituitary to release your own growth hormone in its natural pulsatile pattern.

That's why sermorelin operates via an endogenous-feedback mechanism — it prompts your pituitary to release growth hormone in pulses, the way your body produces GH naturally, and supports your own GH-axis signaling. Sermorelin is available by prescription as a compounded peptide. HGH (recombinant human growth hormone) is a separately regulated drug with FDA-restricted indications. Sermorelin works with your body's own GH-release system, rather than introducing exogenous hormone.

Adults experiencing age-related decline in sleep depth, recovery, and lean-mass maintenance — particularly alongside a GLP-1 (where lean-mass loss is clinically documented in STEP-1 and SURMOUNT-1) or as part of an age-related GH-axis support protocol.

Common patient profiles: adults aged 35-55 experiencing age-related declines in sleep quality and recovery; adults with documented age-related growth hormone decline; GLP-1 patients seeking to mitigate the clinically documented lean-mass loss associated with GLP-1 therapy (STEP-1, SURMOUNT-1).

Sermorelin has 30+ years of clinical use for adult GH-axis support. Documented benefits include increased slow-wave sleep, improved IGF-1 levels, lean-mass preservation, and recovery markers — without the suppression of endogenous GH that exogenous HGH causes.

Sources: Walker RF, Endocrine, 2006. Khorram O et al, JCEM, 1997. Vittone J et al, Metabolism, 1997.

What you get

Everything in your sermorelin kit

No surprises, no upsells. Each shipment includes everything you need to administer safely at home, plus full clinical support.

Compounded sermorelin

Sterile, multi-dose vials. Doses titrated 2.5 → 15 mg by your provider.

Sterile syringes & needles

Pre-paired insulin syringes sized for subcutaneous injection.

Alcohol pads + sharps bin

Everything for safe, sanitary self-administration at home.

Direct provider access

Call or text your U.S.-licensed provider for dose adjustments, side-effect questions, and refills.

Discreet 2-3 day shipping

Insulated, temperature-controlled, plain packaging. Always free.

What the science actually shows

Sermorelin has 30+ years of documented clinical use as an adult GH-axis therapy. The numbers below come from peer-reviewed peptide and endocrinology literature, not marketing.

+SWS

Increased slow-wave (deep) sleep duration

↑ IGF-1

IGF-1 levels move toward optimal range over 12 wk

Lean+

Lean-mass preservation during caloric deficit

Sources: Walker RF, Endocrine, 2006. Khorram O et al, JCEM, 1997. Vittone J et al, Metabolism, 1997. Effects vary by individual.

Customer reviewing her OPTML protocol on her phone

How it works

Start sermorelin in 5 simple steps.

Online assessment to first shipment in under a week. No in-person visits, no waiting rooms.

Start your free assessment →

Take the free assessment

Answer a few questions about your health, weight history, and goals. Takes about 5 minutes online.

Provider reviews your info

A U.S. licensed provider reviews your assessment and prescribes the right dose, if appropriate. You'll hear back from your provider.

Get your kit shipped

If prescribed, your compounded sermorelin, syringes, and supplies ship discreetly in 2-3 days. Free 2-3 day shipping always.

Inject once a week

Self-administer at home. Most patients report reduced cravings and steady weight loss within 2-4 weeks.

Get ongoing support

Message your provider anytime. Dose adjustments, refills, and side-effect questions handled in-app. Cancel anytime.

9:41

Question 1 of 12

What do you want to accomplish with OPTML?

Lose weight
Optimize hormones & recovery
Sleep & recovery
Optimize hormones

Start sermorelin in 5 simple steps

Take the free assessment
Answer a few questions about your sleep, training, and recovery goals — about 5 minutes, all online.
Provider writes an Rx (if appropriate)
Get your kit shipped in 2-3 days
Subcutaneous injection nightly before bed
Get ongoing provider support

Start your free assessment →

No commitment. No insurance needed. See full eligibility & contraindications →

What to expect

Your typical 24-week journey on sermorelin

Based on aggregate clinical-trial data (SURMOUNT-1, NEJM 2022). Individual results vary.

Week 1-2

Days 1-14

Appetite quiets down

Most patients report reduced cravings and earlier fullness within the first two doses. Mild nausea is common; usually fades within a week.

Week 4

−3-5%

First weight change visible

By the end of month one, average reduction is 3-5% of body weight. Energy stabilizes. Provider checks in to titrate dose.

Month 3

−7-10%

Clothes fit differently

Average reduction reaches 7-10% by month three. Most patients are at full therapeutic dose by now. Body composition shifts; not just water.

Month 6

−13-18%

Compounding results

By month six most reach 13-18% reduction. Appetite suppression is sustained. Maintenance dosing discussion begins around month nine.

Source: Jastreboff AM et al. NEJM 2022 (SURMOUNT-1, n=2,539, 72 weeks). 15 mg sermorelin produced average −~30% body weight reduction at 72 weeks vs −3.1% placebo.

Transparent pricing. No surprises.

Compounded sermorelin, provider oversight via call or text, all supplies, and free shipping included.

LegitScript verifiedLicensed US providersHIPAA-protected503A pharmacy

Compounded sermorelin

One flat price.
Every dose.

Daily subcutaneous sermorelin, prescribed and titrated to your sleep and recovery goals. Your monthly price stays the same no matter what dose your provider lands on.

Compounded sermorelin vial
Unlimited messaging with your licensed physician
Sterile syringes & alcohol prep pads
Free 2-3 day discreet shipping
Cancel anytime · HSA/FSA eligible

From

$189 /month— cancel anytime

Or $499 every 3 months — flat retail at every dose.

Start your free assessment →

Daily subcutaneous, dosed to your response. Most operators see deeper REM and faster recovery within the first 4 weeks.

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

Monthly

$189/month— cancel anytime

Billed monthly. Cancel anytime.

Compounded sermorelin
Provider oversight via call or text
Syringes, needles & alcohol pads
Free 2-3 day shipping

Start at $189/mo

Best Value · Save $68

3-month supply

$499/3 months

One shipment, billed quarterly. Cancel anytime.

Compounded sermorelin
Provider oversight via call or text
Syringes, needles & alcohol pads
Free 2-3 day shipping

Start at $499 / 3 mo

Sermorelin FAQs

No. HGH (somatropin) replaces growth hormone directly. Sermorelin is a GHRH peptide that stimulates your pituitary to release your own growth hormone in its natural pulsatile pattern. Cleaner safety profile, preserves your endogenous feedback loop, legal as a prescription compounded peptide.

Daily subcutaneous injection, taken at night before bed on an empty stomach. The timing is intentional: GH release naturally peaks during deep sleep, so dosing then amplifies your body's own pulse rather than creating an unnatural one.

Sleep depth often shifts within the first 1-2 weeks. Recovery improvements show in weeks 3-6. Body-composition changes typically become visible at 8-12 weeks. IGF-1 markers usually move toward optimal range over the first 12 weeks.

Common: mild injection-site reactions (transient redness), occasional warm flushing or vivid dreams in first nights. Less common: mild headache or fluid retention. Most resolve within the first 2-4 weeks.

Contraindicated in active malignancy, pregnancy, breastfeeding, or with severe untreated diabetic retinopathy. Full eligibility & contraindications →

Strongly recommended. Baseline IGF-1 and a basic metabolic panel give your provider a starting point and help dose calibration. The OPTML lab panel is offered as a separate add-on at member rates.

Yes — sermorelin is one of the most-stacked peptides in optimization medicine. It pairs especially well with tirzepatide (lean-mass preservation during fat loss), TRT (recovery + body composition), and NAD+ (cellular energy + sleep). The High-Performer Stack bundles tirz + sermorelin under one provider.

Insulated, temperature-controlled, plain packaging. Free 2-3 day discreet shipping. Vials are stable refrigerated; full storage and reconstitution instructions ship with each kit.

Flat $189/mo — compounded sermorelin, provider oversight via call or text, all syringes, needles, alcohol pads, sharps container, and shipping. Same retail at every dose tier. Lab panels are a separate add-on at member rates. Cancel anytime.

Compounded sermorelin,
prescribed online.