ApoA-I
The main protein component of HDL — the 'good cholesterol' particles.
What is it
Apolipoprotein A-I is the principal protein on HDL particles. It plays a central role in reverse cholesterol transport, moving cholesterol away from artery walls and back to the liver.
Measuring ApoA-I gives a direct look at HDL particle quantity, which is distinct from HDL cholesterol concentration.
Why it's measured
ApoA-I has been linked to cardiovascular protection in published research. Low ApoA-I has been associated with elevated cardiometabolic risk in epidemiologic studies.
Reference range
Standard laboratory reference
> 120 mg/dL
Reference ranges vary by laboratory. Your individual reference range will appear on your test report and should be interpreted by your physician in the context of your overall health profile.
Where does your number land?
—
Drag to your own Apolipoprotein A-I (ApoA-I) result.
Educational only, not a diagnosis. Ranges vary by laboratory. See which panel includes Apolipoprotein A-I (ApoA-I).
What results may indicate
Elevated
Is generally considered favorable in published research on cardiovascular health.
Lower
Has been associated with reduced cholesterol-clearing capacity and elevated cardiometabolic risk in research literature.
These associations are general. They are not a personal diagnosis or prediction. Discuss your individual results with your physician in the context of your full health profile.
When it's measured
ApoA-I is typically included in advanced lipid panels and is not part of a standard cholesterol screen. Discuss testing frequency with your physician.
Related markers
Common questions
Apolipoprotein A-I is the principal protein on HDL particles. It plays a central role in reverse cholesterol transport, moving cholesterol away from artery walls and back to the liver.Measuring ApoA-I gives a direct look at HDL particle quantity, which is distinct from HDL cholesterol concentration.
It's one of the markers used to build a fuller picture of your health. On its own it tells you very little, so it's most informative when reviewed alongside related markers.
It's measured from a standard blood draw at Quest or LabCorp. Apolipoprotein A-I (ApoA-I) is one of the markers included in the OPTML Apex Panel, where your results are read across systems and reviewed by a U.S.-licensed physician.
Reference ranges vary by laboratory, and a single value rarely tells the whole story. Review your result with a physician in the context of your other markers, symptoms, and history.
Apolipoprotein A-I (ApoA-I) is one signal among many. Answer a few quick questions and we’ll point you to the panel that fits.
Measured in
A complete look at your heart, hormones, metabolism, inflammation, and longevity systems — drawn at Quest or LabCorp, reviewed by a U.S.-licensed physician.
Find the right panel →This information is for general educational purposes only and is not medical advice. Lab results alone are not intended to diagnose, treat, or cure any condition and do not replace the advice of a healthcare provider. OPTML does not offer medical advice, a diagnosis, medical treatment, or any form of medical opinion.
OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.
The whole picture in one sitting: who it suits, what the labs decide, what the first year actually looks like. Every clinical claim is cited.
How to protect lean mass while losing weight on a GLP-1.
Double-check your email. A typo means we cannot reach you or resend your guide.
We will send occasional emails you can unsubscribe from at any time. See our Privacy Policy.