Physician-Prescribed Licensed Pharmacy
Hot flashes Brain fog Mood changes Low energy Low sex drive Night sweats Joint aches Weight gain
OPTML for Women
★★★★★4.9 · 200,000+ patients across our provider network

End the night sweats, brain fog, sleep loss. Bioidentical HRT.

Your estradiol and progesterone built your sleep, your mood, your skin, your bones, and your brain. Now they’re leaving. OPTML restores them, physician-led, lab-driven, calibrated to your baseline. Not menopause management. Optimization through restoration.

LegitScript Certified Healthcare MerchantLegitScript CertifiedHealthcare Merchant
  • Bioidentical 17β-estradiol
  • Micronized progesterone
  • Tablet or topical cream
  • Licensed U.S. physicians
Get started Treatment options

Includes a consultation with a U.S.-licensed physician

Starting at $138/mo · Same protocol you’d build with a top menopause specialist, without the 6-month wait.

Scope: bioidentical estradiol (tablet or cream) and oral micronized progesterone. We don’t prescribe injectable estradiol or testosterone for women.

What gets restored

The hormones built you. We bring them back.

Estradiol and progesterone decline through your 40s and into your 50s. They built your sleep, your mood, your skin, your bones, your brain. The symptoms that follow are real, and restoring the hormones to your own baseline addresses them directly.

01

Sleep

In the menopause literature, estrogen and progesterone are associated with improved sleep — progesterone’s GABA-active metabolite supports sleep onset and estradiol supports sleep architecture. Individual results vary.

02

Hot flashes & night sweats

Vasomotor symptoms are among the most-studied responses to estrogen therapy in the menopause literature. Your physician will discuss what to expect for your individual case. Individual results vary.

03

Mood

Mood changes around menopause are commonly discussed in relation to hormonal shifts. Progesterone’s allopregnanolone metabolite is GABA-active. Individual results vary; your physician will discuss what fits your case.

04

Cognition

Cognitive changes around menopause are discussed in the literature in relation to estradiol decline, with the “window of opportunity” (within ~10 years of menopause) an active area of research. Individual results vary.

05

Bone health

Estradiol is well-studied in the literature for postmenopausal bone health, particularly when started within the menopause window. Individual results vary; your physician will discuss what fits your case.

06

Genitourinary

Topical estradiol is discussed in the literature for genitourinary symptoms of menopause, with relatively low systemic absorption. Individual results vary; your physician will discuss what fits your case.

What treatment
may look like

No one-size-fits-all solutions, just one kit with three potential parts for holistic support. After reviewing your intake, a provider will prescribe the combination that's right for you, if you're eligible.

See if I'm eligible

Estradiol pill

Treats hot flashes1
& night sweats

Progesterone pill

Protects
uterine lining2 Better sleep
quality3

Estradiol
vaginal cream

Soothes
irritation4 Relieves
dryness4 Improves
vaginal thinning4

Bundle (estradiol + progesterone): $138/mo · Estradiol alone: from $79/mo · Progesterone: $79/mo

Ready to start

Get started.

5-minute online intake. A U.S. licensed physician reviews your symptoms and prescribes the right protocol — if appropriate. Free discreet shipping, included in your price.

Get started → No insurance needed · HSA/FSA eligible · Cancel anytime
Not sure where to start?

Get your bloodwork first.

Your baseline estradiol, progesterone, FSH, LH, thyroid, and metabolic markers — in one draw at any Quest Diagnostics. Use the results to decide if you actually need HRT, and at what dose.

Order Optimized Health, Female — $229 → CLIA-certified labs · Written physician protocol in 48-72 hrs · See all panels
The science

Find your balance

Declining estrogen levels can throw off your cycle, energy, and more, but it's not your new normal. Treatment plans through OPTML are designed to gently restore your levels and bring everything back into balance.

Start my assessment

Graph for illustrative purposes only. Individual hormone levels may vary.

Start HRT in 4 simple steps.

01

Start your online visit

Answer a few questions about your symptoms, cycle, and history, all online—no in-person doctor's office visit necessary.

02

Provider evaluation

A U.S.-licensed provider reviews your intake and labs, then prescribes the right protocol, if appropriate.

03

Personalized plan

Compounded HRT and supplies. Free discreet shipping. Molecule, format, and dose tailored to you.

04

Ongoing support

Message your provider anytime. Symptom and lab re-checks at week 8–12.

Want the full screening checklist? Read the HRT eligibility & contraindications →

Not sure if HRT is right for you?
Take the 3-minute Perimenopause Symptom Score →
Validated Greene Climacteric Scale. Scores symptoms across 4 domains. Routes to the right protocol.

Find your balance

Declining estrogen levels can throw off your cycle, energy, and more, but it's not your new normal. Treatment plans through OPTML are designed to gently restore your levels and bring everything back into balance.

Start my assessment
Free clinical tools · No login · No email

Know your numbers before you book.

All free tools →
Symptoms

Perimenopause Score

Greene Climacteric Scale

→ Eligibility

Find My HRT Protocol

60-sec personalized plan

→ Labs

Hormone Lab Decoder

Estradiol · FSH · Progesterone

→ Cost

HRT Savings Calculator

vs. specialist clinic

→

OPTML for Women: hormones, restored · Starting at $138/mo

Get started →

Transparent pricing

Physician-directed care

A U.S.-licensed physician personally reviews every order before anything is prescribed.

  • U.S.-licensed physicians
  • Reviews every order
  • LegitScript Certified
  • 503A pharmacy · USP <797>
Progesterone
$79/month— cancel anytime

Micronized, oral, bedtime.

  • 100mg or 200mg
  • Provider-titrated
  • Free discreet shipping
See progesterone details
Estradiol Tablet
$79/month

Most common starting format.

  • Bioidentical 17β-estradiol
  • Daily oral
  • Provider-titrated
See estradiol details
Most Popular
HRT Bundle
$138/month

Estradiol + progesterone together.

  • Estradiol tablet
  • Micronized progesterone
  • Provider-titrated
  • Free discreet shipping
Start HRT, $138/mo
Estradiol Cream
$199/month

Topical or vaginal application.

  • Lower systemic load
  • Flexible dosing
  • Genitourinary focus
See estradiol details

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

No surprises

Side effects, told straight.

Bioidentical HRT (estradiol + micronized progesterone) has decades of safety data. Most patients tolerate it well, here's what to actually expect.

Common >10%

  • Mild breast tenderness (especially first 4-8 weeks)
  • Spotting or breakthrough bleeding (perimenopausal patients)
  • Bloating or fluid retention
  • Drowsiness from progesterone (usually a feature, taken at bedtime)

Most resolve within 4-8 weeks as your body adjusts.

Less common 1-10%

  • Headache, especially when starting
  • Nausea (can switch from oral to topical to fix)
  • Mood changes
  • Skin reaction (topical cream)

Provider can switch dose, format, or timing, usually fixes these.

Rare but serious <1%

  • Blood clots (DVT/PE), risk lower with transdermal than oral
  • Stroke (very rare in healthy women under 60)
  • Gallbladder issues
  • Endometrial changes (why we always pair estradiol with progesterone)

Contraindicated

  • Active or history of breast cancer
  • Active or history of blood clots / DVT / PE
  • Active liver disease
  • Unexplained vaginal bleeding
  • Pregnancy
Call your provider right away if you experience leg swelling, chest pain, sudden severe headache, vision changes, or new breast lumps. The "window of opportunity", within 10 years of menopause or before age 60, is when HRT shows the strongest benefit-to-risk profile.

Prescribed by board-certified U.S.-licensed clinicians

Licensed in all 50 states · Meet your care team

→
After you order

Expected time from order to your door.

Your medication is not sitting on a shelf waiting for you. It is prepared for you, to your prescription, after a physician has read your file — and that is the reason for the wait. Here is where every day goes.

7–10 days
from ordering to it arriving, for a straightforward protocol. Roughly 5–7 days for the physician and the pharmacy, then 2–3 days in transit.
Your online visitabout 10 minutes

Done from your kitchen table, not a waiting room. No appointment to book, no clinic to drive to, no time off work. You answer questions about your health and your goals, and that is the whole of your part in it.

A physician actually reads your filethe slow part, on purpose

A U.S.-licensed physician goes through what you submitted, and your lab work where your protocol calls for it. This is a real clinical decision made by a real person, which is why it takes days rather than minutes — and it is the step you would least want us to rush.

Some protocols need a further conversation, or bloodwork first. TRT, enclomiphene and HRT commonly do.

Your medication is made for younot off a shelf

Once a physician approves it, your prescription goes to a state-licensed, FDA-registered 503A compounding pharmacy, where it is prepared for you individually under USP <797> sterility standards.

That is what compounding means: it is made to your prescription after it is written, rather than manufactured in advance and picked from stock. It is also why this is measured in days. Compounded preparations are not FDA-approved.

It ships to your door2–3 days

Insulated and temperature-controlled, in plain packaging with no medical branding on the outside. Shipping is free and already in your price, and tracking is emailed when it leaves.

The one thing that holds an order upworth reading

An order pauses if something is still outstanding on your side — an intake form you have not finished, ID verification, or lab work. It is the most common reason an order goes quiet, and the system cannot always alert you when it happens.

So if it has been quiet for a couple of days, check your email and your patient portal before anything else. That is nearly always where the missing piece is, and clearing it starts your order moving again immediately. Full checklist here.

Ordering on a Friday or at the weekend

Orders are processed seven days a week. What is not covered at weekends is anything needing a person — a stuck form, an ID check, a question for your provider. Order late on a Friday and you will likely hear more at the start of the week.

How to check where you are

Your patient portal shows the live stage of your order. If your purchase appears there and you have the confirmation email, you are in the queue and nothing is wrong.

These are typical ranges, not guarantees, and delays do happen. Something look wrong? Email info@optml.health and a person will pick it up. For anything clinical, message your physician in the portal. For emergencies, call 911.

Common questions

HRT, answered.

The most common questions our medical team hears about hormone replacement therapy, answered with the current evidence, not the 2002 headlines.

01What is HRT?

Hormone replacement therapy restores the estradiol and progesterone your body produces less of during perimenopause and after menopause. It addresses hot flashes, sleep disruption, mood changes, vaginal dryness, brain fog, and bone density loss.

02When should I start HRT?

The evidence-based "window of opportunity" is within 10 years of your last period or before age 60, when HRT shows the strongest cardiovascular, cognitive, and bone-density benefits with the lowest risk profile. Many providers now consider perimenopausal HRT (in your 40s, before periods stop) appropriate as well.

03Do I need both estradiol and progesterone?

If you have an intact uterus: yes. Unopposed estrogen raises endometrial cancer risk; progesterone protects the endometrium. If you've had a hysterectomy, estradiol alone is typically sufficient. Your provider determines this during intake.

04Bioidentical vs synthetic, what's the difference?

Bioidentical hormones (17β-estradiol and micronized progesterone) are molecularly identical to what your body produces. Older synthetic regimens (older synthetic regimens) are different molecules with different metabolic profiles and slightly different risk profiles. OPTML prescribes bioidentical, which is the modern standard.

05Is HRT safe for me?

For healthy women starting within 10 years of menopause, modern bioidentical HRT is associated with reduced cardiovascular and all-cause mortality. Concerns from a widely-discussed early-2000s women's health study largely applied to older synthetic hormone regimens started in women a decade or more past menopause. The current evidence base is dramatically more nuanced and favorable.

06How quickly will I feel something?

In the menopause literature, symptom changes are often discussed within the first weeks, with bone and other long-term effects accruing over time. Individual results vary; your physician will discuss what to expect for your case.

07Who shouldn't use HRT?

Patients with active estrogen-dependent cancer, unexplained vaginal bleeding, active liver disease, or recent stroke/MI should not start systemic HRT. Your provider screens for these.

Mechanism reference · scroll to see the shift

Watch the cluster shift from declining to restored.

Hot flashes & night sweatsResolved
Sleep depth & continuityDeeper
Brain clarity / word-findingRestored
Mood stability & calmSteady
Joint comfortSupported
Genitourinary comfortRestored

Mechanism reference based on published research on bioidentical estradiol + micronized progesterone therapy (ACOG Practice Bulletin 141; the clinical literature CPG, 2015). Compounded preparations are not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. Not a prediction of personal outcomes. Individual response varies.

What restoration feels like

What HRT customers across our provider network are saying

Ready when you are

Three ways to get started.

Most patients are matched to a protocol within 5 minutes. Pick whichever path fits where you're at right now.

Get started 5-minute intake, physician-reviewed Take the 90-second quiz Find the right protocol for you Ask the OPTML assistant Questions answered in seconds

Important safety information

HRT is a serious prescription protocol with real contraindications. Read the full eligibility, side effects, and warnings before starting. Not appropriate for women with active or history of breast or endometrial cancer, untreated DVT/PE, severe liver disease, or unexplained vaginal bleeding.

Your HRT protocol comes with the whole system

  • A physician consultation and ongoing care — reviewed and adjusted by a U.S.-licensed physician, not billed separately.
  • The OPTML 30 — a 30-day starter: mindset, a customizable meal plan, and a gym-or-dumbbell workout.
  • Free tools — daily protein target, TDEE, calorie math, and more.

Included free with your active HRT protocol. No separate membership, no add-on charges.

Weight-loss medication disclaimer

OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.

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