How much do they cost?

Compounded semaglutide starts at $249/month. Compounded tirzepatide starts at $349/month. Both include the provider consult, medication, supplies, and ongoing messaging. HSA and FSA accepted.

Two GLP-1 protocols · One online consult

Two GLP-1s. One protocol. Choose the right fit.

Q: How are OPTML compounded GLP-1 preparations made?

OPTML dispenses compounded preparations of semaglutide and tirzepatide made to prescription by FDA-registered 503A pharmacies under USP 797 sterility standards, on prescription by U.S. licensed physicians. Compounded medications are not FDA-approved.

Q: Are the side effects different?

Both have similar GI side effect profiles — nausea, constipation, and occasional fatigue, especially during dose escalation. Tirzepatide's dual-receptor mechanism can produce slightly more pronounced GI effects in some patients. Your provider titrates slowly to minimize discomfort.

Two GLP-1 molecules used in physician-supervised weight-management protocols. Semaglutide acts on the GLP-1 receptor; tirzepatide adds GIP-receptor activity for a different appetite-modulation profile. OPTML dispenses both as compounded preparations under U.S. licensed-physician prescription.

All-inclusive pricing — no membership fees
Provider-matched: tirzepatide or semaglutide
503A licensed pharmacies (USP <797>) · Cancel anytime
Only at OPTML
GLP-1 Muscle Loss Protocol included
Educational guide on muscle preservation during physician-supervised GLP-1 protocols.

Get started See the comparison →

Includes a consultation with a U.S.-licensed physician

Compounded medication is not FDA-approved. Sema $249/mo · Tirz $349/mo · HSA/FSA eligible.

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Prescription only Prescribed by U.S.-licensed physicians

Weight Loss · GLP-1

Prescribed by U.S.-licensed physicians

Two GLP-1s. One protocol. Choose the right fit.

Tirzepatide and semaglutide are both prescribed online by U.S. licensed providers, compounded at 503A pharmacies, and shipped to your door monthly. Your provider helps you choose based on your starting weight, goals, and how your body responds.

All-inclusive pricing — no membership fees
503A licensed pharmacies (USP <797>)
U.S.-licensed providers · Cancel anytime
GLP-1 Muscle Loss Protocol included

Get started See the comparison

Starting at $249/mo · Free provider consult · HSA/FSA eligible

Step 1 of 3 · Choose your GLP-1

Tirzepatide or semaglutide? It depends on your goal.

Both are compounded GLP-1 medications, prescribed and overseen by U.S.-licensed providers. Your provider helps you choose based on your starting weight, side-effect tolerance, and clinical goals.

Tirzepatide

A dual GIP / GLP-1 receptor agonist.

Acts on both GIP and GLP-1 receptors, which the literature describes as having a stronger appetite-modulation profile than GLP-1 alone. Used in physician-supervised weight-management protocols. OPTML dispenses the compounded preparation under U.S. licensed-physician prescription; compounded medications are not FDA-approved.

Start tirzepatide $349/mo · physician oversight included

Semaglutide

A GLP-1 receptor agonist.

Acts on the GLP-1 receptor: reduces hunger signaling and slows gastric emptying. Used in physician-supervised weight-management protocols. OPTML dispenses the compounded preparation under U.S. licensed-physician prescription; compounded medications are not FDA-approved.

Start semaglutide $249/mo · physician oversight included

Tirzepatide · Dual-receptor

Compounded Tirzepatide

A dual GIP / GLP-1 receptor agonist used in physician-supervised weight-management protocols. Acts on two complementary appetite-regulation pathways. Compounded medications are not FDA-approved.

Dual receptor action (GIP + GLP-1) for stronger appetite modulation
Dual GIP/GLP-1 mechanism, appetite + glucose
Once-weekly subcutaneous injection
Standard titration: 2.5 → 5 → 7.5 → 10 → 15 mg

$349/mo · provider consult included

Start tirzepatide Learn more

Semaglutide · GLP-1

Compounded Semaglutide

A GLP-1 receptor agonist used in physician-supervised weight-management protocols. Reduces hunger signaling and slows gastric emptying. Compounded medications are not FDA-approved.

Single-receptor action: GLP-1 reduces hunger + slows gastric emptying
Single GLP-1 receptor mechanism
Once-weekly subcutaneous injection
Standard titration: 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg

$249/mo · provider consult included

Start semaglutide Learn more

Not sure which fits? Take the 60-second protocol quiz, your provider routes you based on starting weight, goals, and tolerance.

The Rebound Cycle

80%

Roughly 8 in 10 people who lose weight through dieting alone regain it. Not because they quit. Because their biology fought back.

Wing & Phelan, Am J Clin Nutr 2005 · Sumithran et al., NEJM 2011 · Fothergill et al., Obesity 2016

How many times have you lost 10+ lbs?

Current weight 220lbs

Goal weight 180lbs

Weight you may have lost and regained

100lbs

2.5 cycles × 40 lb gap

The work was real every single time. But the body fights to keep weight on, and that pushback is biology, not a lack of discipline.

You were never the problem.
Your biology was.

And biology is something a U.S. licensed physician can measure and treat. They review your history, run your labs, and determine whether prescription treatment is appropriate for you.

Get started

Where these numbers come from

Long-term studies of dieting consistently find most lost weight is regained within 3 to 5 years (Wing & Phelan, Am J Clin Nutr 2005). After weight loss, ghrelin rises and leptin falls, and these shifts persist for at least a year (Sumithran et al., NEJM 2011). Resting metabolic rate can stay suppressed for years (Fothergill et al., Obesity 2016). Figures describe research populations and dieting in general; they are educational, not a prediction of your results or a claim about any treatment.

Step 3 of 3 · How it works

Start your GLP-1 in 4 simple steps.

Lab review, physician oversight, and medication shipped to your door, same protocol whether you choose tirzepatide or semaglutide.

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.

Provider evaluation

A U.S.-licensed provider reviews your intake and prescribes tirzepatide or semaglutide, if appropriate.

Personalized plan

Compounded GLP-1, syringes, and supplies arrive in 2–3 days. Titration tailored to you.

Ongoing support

Message your provider anytime. Dose adjustments, refills, and questions handled in-app.

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Question 1 of 12

What do you want to accomplish with OPTML?

Lose weight
Energy & vitality
Sleep & recovery
Optimize hormones

Start losing weight in 4 simple steps

Start your online visit
Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.
Provider evaluation
Personalized plan
Ongoing support

Frequently asked questions

Semaglutide is a GLP-1 receptor agonist. Tirzepatide is a dual GIP and GLP-1 receptor agonist. The literature describes the dual mechanism as having a stronger appetite-modulation profile in some populations. Your physician helps you decide based on your starting weight, side-effect tolerance, and budget.

OPTML's compounded preparations of semaglutide and tirzepatide are made to your specific prescription by FDA-registered 503A pharmacies under USP <797> sterility standards, on prescription by U.S. licensed physicians. Compounded medications are not FDA-approved.

Yes. Many patients start on semaglutide and switch to tirzepatide if they want a stronger response or plateau. Your provider handles the transition and dose recalibration.

Both have similar GI side effect profiles, nausea, constipation, and occasional fatigue, especially during dose escalation. Tirzepatide's dual-receptor mechanism can produce slightly more pronounced GI effects in some patients. Your provider titrates slowly to minimize discomfort.

Compounded semaglutide starts at $249/mo. Compounded tirzepatide starts at $349/mo. Both include the provider consult, medication, supplies, and ongoing messaging. HSA/FSA eligible.

OPTML services all 50 states with licensed telehealth providers. Some states require additional documentation, we'll let you know during intake.

Weight-loss medication disclaimer. OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.

Two GLP-1s. One protocol. Choose the right fit.

Two GLP-1s. One protocol. Choose the right fit.