Two GLP-1 molecules used in physician-supervised weight-management protocols. Semaglutide acts on the GLP-1 receptor; tirzepatide adds GIP-receptor activity for a different appetite-modulation profile. OPTML dispenses both as compounded preparations under U.S. licensed-physician prescription.
Includes a consultation with a U.S.-licensed physician
Compounded medication is not FDA-approved. Sema $249/mo · Tirz $349/mo · HSA/FSA eligible.
LegitScript CertifiedHealthcare Merchant
Prescription only
Tirzepatide and semaglutide are both prescribed online by U.S. licensed providers, compounded at 503A pharmacies, and shipped to your door monthly. Your provider helps you choose based on your starting weight, goals, and how your body responds.
Starting at $249/mo · Free provider consult · HSA/FSA eligible
Both are compounded GLP-1 medications, prescribed and overseen by U.S.-licensed providers. Your provider helps you choose based on your starting weight, side-effect tolerance, and clinical goals.
Acts on both GIP and GLP-1 receptors, which the literature describes as having a stronger appetite-modulation profile than GLP-1 alone. Used in physician-supervised weight-management protocols. OPTML dispenses the compounded preparation under U.S. licensed-physician prescription; compounded medications are not FDA-approved.
Start tirzepatideActs on the GLP-1 receptor: reduces hunger signaling and slows gastric emptying. Used in physician-supervised weight-management protocols. OPTML dispenses the compounded preparation under U.S. licensed-physician prescription; compounded medications are not FDA-approved.
Start semaglutide
A dual GIP / GLP-1 receptor agonist used in physician-supervised weight-management protocols. Acts on two complementary appetite-regulation pathways. Compounded medications are not FDA-approved.
A GLP-1 receptor agonist used in physician-supervised weight-management protocols. Reduces hunger signaling and slows gastric emptying. Compounded medications are not FDA-approved.
Not sure which fits? Take the 60-second protocol quiz, your provider routes you based on starting weight, goals, and tolerance.
Roughly 8 in 10 people who lose weight through dieting alone regain it. Not because they quit. Because their biology fought back.
Wing & Phelan, Am J Clin Nutr 2005 · Sumithran et al., NEJM 2011 · Fothergill et al., Obesity 2016
The work was real every single time. But the body fights to keep weight on, and that pushback is biology, not a lack of discipline.
And biology is something a U.S. licensed physician can measure and treat. They review your history, run your labs, and determine whether prescription treatment is appropriate for you.
Long-term studies of dieting consistently find most lost weight is regained within 3 to 5 years (Wing & Phelan, Am J Clin Nutr 2005). After weight loss, ghrelin rises and leptin falls, and these shifts persist for at least a year (Sumithran et al., NEJM 2011). Resting metabolic rate can stay suppressed for years (Fothergill et al., Obesity 2016). Figures describe research populations and dieting in general; they are educational, not a prediction of your results or a claim about any treatment.
Lab review, physician oversight, and medication shipped to your door, same protocol whether you choose tirzepatide or semaglutide.
Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.
A U.S.-licensed provider reviews your intake and prescribes tirzepatide or semaglutide, if appropriate.
Compounded GLP-1, syringes, and supplies. Free discreet shipping. Titration tailored to you.
Message your provider anytime. Dose adjustments, refills, and questions handled in-app.
Question 1 of 12
Start losing weight in 4 simple steps
Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.
Your medication is not sitting on a shelf waiting for you. It is prepared for you, to your prescription, after a physician has read your file — and that is the reason for the wait. Here is where every day goes.
Done from your kitchen table, not a waiting room. No appointment to book, no clinic to drive to, no time off work. You answer questions about your health and your goals, and that is the whole of your part in it.
A U.S.-licensed physician goes through what you submitted, and your lab work where your protocol calls for it. This is a real clinical decision made by a real person, which is why it takes days rather than minutes — and it is the step you would least want us to rush.
Some protocols need a further conversation, or bloodwork first. TRT, enclomiphene and HRT commonly do.
Once a physician approves it, your prescription goes to a state-licensed, FDA-registered 503A compounding pharmacy, where it is prepared for you individually under USP <797> sterility standards.
That is what compounding means: it is made to your prescription after it is written, rather than manufactured in advance and picked from stock. It is also why this is measured in days. Compounded preparations are not FDA-approved.
Insulated and temperature-controlled, in plain packaging with no medical branding on the outside. Shipping is free and already in your price, and tracking is emailed when it leaves.
An order pauses if something is still outstanding on your side — an intake form you have not finished, ID verification, or lab work. It is the most common reason an order goes quiet, and the system cannot always alert you when it happens.
So if it has been quiet for a couple of days, check your email and your patient portal before anything else. That is nearly always where the missing piece is, and clearing it starts your order moving again immediately. Full checklist here.
Orders are processed seven days a week. What is not covered at weekends is anything needing a person — a stuck form, an ID check, a question for your provider. Order late on a Friday and you will likely hear more at the start of the week.
Your patient portal shows the live stage of your order. If your purchase appears there and you have the confirmation email, you are in the queue and nothing is wrong.
These are typical ranges, not guarantees, and delays do happen. Something look wrong? Email info@optml.health and a person will pick it up. For anything clinical, message your physician in the portal. For emergencies, call 911.
Prescribed by board-certified U.S.-licensed clinicians
Licensed in all 50 states · Meet your care team
Free consult. No insurance required. Cancel anytime. Your provider chooses the right molecule for your goals.
LegitScript CertifiedHealthcare Merchant
5-minute online consult. Your provider matches tirzepatide or semaglutide to your starting weight and goals. Free discreet shipping, included in your price.
OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.
The whole picture in one sitting: who it suits, what the labs decide, what the first year actually looks like. Every clinical claim is cited.
How to protect lean mass while losing weight on a GLP-1.
Double-check your email. A typo means we cannot reach you or resend your guide.
We will send occasional emails you can unsubscribe from at any time. See our Privacy Policy.