What are the side effects?

Most common: nausea, constipation, diarrhea, fatigue, typically mild and temporary. Side effect profile is similar to semaglutide. Your provider starts you at a low dose and titrates up slowly.

How is NAD+ taken — and when?

Daily subcutaneous injection. Most patients take it in the morning to support the day's energy curve.

Can I stack NAD+ with other protocols?

Yes. Many patients switch for stronger results or fewer GI side effects. Your OPTML provider will manage the transition and titration plan.

Do I need labs before starting?

Not always required, but strongly recommended. We offer an optional comprehensive metabolic panel to establish baseline markers before starting treatment.

Cellular energy · Longevity · Mitochondrial support

Compounded NAD+,
prescribed online.

NAD+ is the cofactor that powers nearly every metabolic process in your cells — energy production, DNA repair, mitochondrial health. Levels decline sharply with age. Subcutaneous NAD+ rebuilds the cellular fuel your body has lost. Prescribed by U.S.-licensed providers, shipped to your door.

Cellular energy + mitochondrial support
DNA repair + sirtuin activation
Free 2-3 day discreet shipping
Free provider consult · cancel anytime

Get started How it works →

Compounded medication is not FDA-approved. Starting at $179/mo · HSA/FSA eligible.

LegitScript CertifiedHealthcare Merchant

Prescription only 4.9 · 200,000+ patients

Longevity · Cellular energy

★★★★★4.9 / 200,000+ patients across our provider network

Restore the cellular fuel your body has lost.

✓ Licensed US providers✓ 2-3 day discreet shipping✓ Cancel anytime

LegitScript CertifiedHealthcare Merchant

NAD+ is the molecule your mitochondria use to make energy. Levels drop ~50% by age 50, and the consequences cascade: fatigue, slower recovery, dimmer cognition, accelerated cellular aging. Restoring NAD+ restores the substrate your cells need to function.

Cellular energy + clarity
Mitochondrial support
Subcutaneous injection
Cancel anytime

Start your free assessment How it works

Starting at $179/mo · Free provider consult · HSA/FSA eligible

What to expect on NAD+

A timeline grounded in cellular biology.

Wk 1-2

Energy + mental clarity

Most patients notice a lift in mental sharpness, focus duration, and afternoon energy within the first 7-14 days.

Wk 3-6

Recovery + sleep depth

Sleep deepens. Soreness shortens. Patients often describe a return to "feeling 35 again" — clearer mornings, less afternoon crash.

Wk 8-12

Mitochondrial function lifts

Sustained lift in baseline energy. Patients describe "the floor moving up" — more capacity for training, work, and life.

Wk 12+

Sustained NAD+ baseline

Cellular energy gains compound. Provider re-evaluates every 12 weeks and adjusts dose or delivery format.

Timeline reflects typical clinical experience and published NAD+ supplementation literature. Individual results vary.

With NAD+ vs Without · scroll to see the shift

Watch your baseline go from flat to firing.

Cellular NAD+ declines by roughly 50% between age 30 and 60. The drop drags down energy, sleep, recovery, and repair. Keep scrolling — watch the same six systems shift from red (declining) to green (restored).

Cellular energy & ATP production Restored

Mitochondrial function Upregulated

Sleep quality & deep REM Deeper

Mental clarity & focus Sharper

DNA repair & sirtuin activation Active

Recovery & inflammation markers Improving

Patient-reported outcomes from physician-monitored NAD+ protocols. Mechanism well-established (Verdin, Science, 2015; Yoshino et al., Cell Metabolism, 2018). Individual results vary.

NAD+, explained

The molecule your mitochondria need.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell of your body. It's the molecule your mitochondria use to convert nutrients into ATP — the actual energy currency that powers everything from heartbeat to thought.

NAD+ levels drop ~50% between age 30 and 50. The consequences cascade: fatigue, slower recovery, dimmer cognition, reduced metabolic flexibility, accelerated cellular aging.

Daily subcutaneous injection. Pharmaceutical-grade NAD+ delivered directly under the skin — fastest onset, highest absorption, most reliable serum levels.

The injection is small (insulin-syringe size), virtually painless, and takes seconds to administer at home each morning.

Anyone over 35 who's noticed their baseline energy isn't what it used to be — afternoon crashes, slower recovery, "fog" that wasn't there before. Also patients pursuing longevity protocols who want mitochondrial support alongside other interventions.

NAD+ pairs naturally with TRT, HRT, and sermorelin — addressing the cellular layer that hormones and peptides depend on.

NAD+ is one of the most-studied molecules in longevity research. Documented effects include improved mitochondrial respiration, sirtuin activation, DNA repair, and metabolic flexibility. Clinical NAD+ supplementation has shown improvements in fatigue, sleep, and recovery markers in adult populations.

Sources: Verdin E, Science, 2015. Yoshino J et al, Cell Metabolism, 2018. Martens CR et al, Nature Communications, 2018.

What you get

Everything in your NAD+ kit

No surprises, no upsells. Each shipment includes everything you need to administer safely at home, plus full clinical support.

OPTML NAD+ kit: alcohol prep pad, vial, and pre-paired syringe

NAD+ subcutaneous injection

Pharmaceutical-grade NAD+ delivered as a daily subcutaneous injection. Fastest onset, highest absorption.

Sterile syringes & needles

Pre-paired insulin syringes sized for subcutaneous injection.

Alcohol pads + sharps bin

Everything for safe, sanitary self-administration at home.

Direct provider access

Call or text your U.S.-licensed provider for dose adjustments and questions.

Discreet 2-3 day shipping

Insulated, temperature-controlled, plain packaging. Always free.

What the science actually shows

NAD+ is among the most-studied molecules in longevity science. The numbers below reflect documented effects in human supplementation studies and adult mitochondrial-function literature.

↑ ATP

Mitochondrial respiration + cellular ATP output

↑ Sirt

Sirtuin activation (DNA repair, longevity pathways)

Energy

Sustained baseline energy + reduced fatigue

Sources: Verdin E, Science, 2015. Yoshino J et al, Cell Metabolism, 2018. Martens CR et al, Nature Communications, 2018. Effects vary by individual.

Customer reviewing her OPTML protocol on her phone

How it works

Start NAD+ in 5 simple steps.

Online assessment to first shipment in under a week. No in-person visits, no waiting rooms.

Start your free assessment →

Take the free assessment

Answer a few questions about your health, weight history, and goals. Takes about 5 minutes online.

Provider reviews your info

A U.S. licensed provider reviews your assessment and prescribes the right dose, if appropriate. You'll hear back from your provider.

Get your kit shipped

If prescribed, your NAD+ vial, syringes, and supplies ship discreetly in 2-3 days. Free 2-3 day shipping always.

Inject once a week

Self-administer at home. Most patients report reduced cravings and steady weight loss within 2-4 weeks.

Get ongoing support

Message your provider anytime. Dose adjustments, refills, and side-effect questions handled in-app. Cancel anytime.

9:41

Question 1 of 12

What do you want to accomplish with OPTML?

Lose weight
Build muscle & performance
Cellular energy & longevity
Optimize hormones

Start NAD+ in 5 simple steps

Take the free assessment
Answer a few questions about your energy, recovery, and longevity goals — about 5 minutes, all online.
Provider writes an Rx (if appropriate)
Get your kit shipped in 2-3 days
Subcutaneous injection (typically morning)
Get ongoing provider support

Start your free assessment →

No commitment. No insurance needed. See full eligibility & contraindications →

What to expect

Your typical 12-week journey on NAD+

Based on aggregate clinical-trial data (SURMOUNT-1, NEJM 2022). Individual results vary.

Week 1-2

Days 1-14

Appetite quiets down

Most patients report reduced cravings and earlier fullness within the first two doses. Mild nausea is common; usually fades within a week.

Week 4

−3-5%

First weight change visible

By the end of month one, average reduction is 3-5% of body weight. Energy stabilizes. Provider checks in to titrate dose.

Month 3

−7-10%

Clothes fit differently

Average reduction reaches 7-10% by month three. Most patients are at full therapeutic dose by now. Body composition shifts; not just water.

Month 6

−13-18%

Compounding results

By month six most reach 13-18% reduction. Appetite suppression is sustained. Maintenance dosing discussion begins around month nine.

Sources: Verdin E, Science, 2015. Yoshino J et al, Cell Metabolism, 2018. Martens CR et al, Nature Communications, 2018 (NAD+ supplementation in adults).

Transparent pricing. No surprises.

NAD+, provider oversight via call or text, all supplies, and free shipping included.

LegitScript verifiedLicensed US providersHIPAA-protected503A pharmacy

Compounded NAD+

One flat price.
Every dose.

Subcutaneous NAD+ prescribed and titrated to your response. Your monthly price stays the same regardless of dose tier.

Compounded NAD+ vial
Unlimited messaging with your licensed physician
Sterile syringes & alcohol prep pads
Free 2-3 day discreet shipping
Cancel anytime · HSA/FSA eligible

From

$179 /month— cancel anytime

Or $489 every 3 months — flat retail at every dose.

Start your free assessment →

Daily subcutaneous, dosed to your response. Patients typically take it in the morning to support the day’s energy curve.

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

Monthly

$179/month— cancel anytime

Billed monthly. Cancel anytime.

NAD+ subcutaneous injection
Provider oversight via call or text
All supplies (syringes, alcohol pads)
Free 2-3 day shipping

Start at $179/mo

Best Value · Save $48

3-month supply

$489/3 months

One shipment, billed quarterly. Cancel anytime.

NAD+ subcutaneous injection
Provider oversight via call or text
All supplies (syringes, alcohol pads)
Free 2-3 day shipping

Start at $489 / 3 mo

OPTML High-Performer Stack: compounded tirzepatide and sermorelin vials

Better Together

The High-Performer Stack: tirzepatide + sermorelin.

NAD+ supplies the cellular substrate. Tirzepatide and sermorelin supply the signals. The Stack pairs the two medications most operators run together — fat loss with muscle protection. NAD+ amplifies both.

Explore the High-Performer Stack →

NAD+ FAQs

Not exactly. NMN and NR are NAD+ precursors — your body has to convert them. NAD+ subcutaneous injection delivers the molecule directly. Faster onset, higher serum levels, more reliable absorption — at the cost of a prescription requirement and clinical oversight.

Daily subcutaneous injection, taken in the morning to support the day's energy curve. The injection is small (insulin-syringe size) and takes seconds. Split dosing also works for some patients.

Energy and mental clarity often shift within the first 7-14 days. Sleep depth and recovery improvements show in weeks 3-6. Sustained baseline lift compounds over 8-12 weeks as cellular NAD+ pools rebuild.

Common: mild injection-site reactions (transient redness), occasional warm flushing or vivid dreams in first nights. Less common: mild headache or fluid retention. Most resolve within the first 2-4 weeks.

Contraindicated in active malignancy, pregnancy, breastfeeding, or with severe untreated diabetic retinopathy. Full eligibility & contraindications →

Not always required, but a baseline metabolic panel is recommended for patients pursuing comprehensive longevity protocols. The OPTML lab panel is offered as a separate add-on at member rates.

Yes — NAD+ is the most stackable molecule on the menu. It pairs naturally with TRT, HRT, and sermorelin because it supplies the cellular substrate hormones and peptides depend on. Many longevity-minded patients run NAD+ as a continuous baseline protocol.

Insulated, temperature-controlled, plain packaging. Free 2-3 day discreet shipping. Vials are stable refrigerated; full storage and reconstitution instructions ship with each kit.

Flat $179/mo for the monthly plan, or $489 every 3 months for the 3-month supply (saves $48 over 3 months). Includes the medication, provider oversight via call or text, all supplies (syringes, needles, alcohol pads), and shipping. Lab panels are a separate add-on at member rates. Cancel anytime.

Compounded NAD+,
prescribed online.