Cellular energy · Longevity · Mitochondrial support

Restore the cellular fuel your body has lost.

NAD+ is the cofactor that powers nearly every metabolic process in your cells — energy production, DNA repair, mitochondrial health. Levels decline sharply with age. Subcutaneous NAD+ rebuilds the cellular fuel your body has lost. Prescribed by U.S.-licensed providers, shipped to your door.

  • Cellular energy + mitochondrial support
  • DNA repair + sirtuin activation
  • Free discreet shipping
  • Free provider consult · cancel anytime

Includes a consultation with a U.S.-licensed physician

Compounded medication is not FDA-approved. Starting at $179/mo · HSA/FSA eligible.

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OPTML compounded NAD+ vial Prescription only 4.9 · 200,000+ patients across our provider network
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Longevity · Cellular energy
★★★★★4.9 · 200,000+ patients across our provider network

Restore the cellular fuel your body has lost.

Licensed US providers Free discreet shipping Cancel anytime

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NAD+ is the molecule your mitochondria use to make energy. Levels drop ~50% by age 50, and the consequences cascade: fatigue, slower recovery, dimmer cognition, accelerated cellular aging. Restoring NAD+ restores the substrate your cells need to function.

  • Cellular energy + clarity
  • Mitochondrial support
  • Subcutaneous injection
  • Cancel anytime

Starting at $179/mo · Free provider consult · HSA/FSA eligible

The biology of aging

NAD+ powers your cells. Aging makes it harder to keep up.

NAD+ is a coenzyme in nearly every cell, central to energy and DNA repair. Research links aging to lower NAD+ in many tissues. Explore what it does, what affects it, and the pattern researchers see.

45
your age on the
NAD+ research curve
Tissue NAD+ vs young-adult range
70% (illustrative)
young-adult 20 50 80
Drag to your age45 yrs
What research links to NAD+
Exercise Sleep Fasting Sun / UV exposure Inflammation Age

General educational information about NAD+ biology and how it is studied in relation to aging. Research on NAD+ and age is evolving and not fully settled: human studies of whole-blood NAD+ have produced mixed results, while direct measurements in tissues such as muscle, brain, and skin more consistently show age-related decline. The curve and percentages are illustrative of a general research pattern, not your levels, not a measurement of any individual, and not a prediction. This makes no claim about any product, medication, or supplement, and does not state or imply that anything offered on this page changes NAD+ levels. What your own status is, and whether anything is appropriate for you, is determined by a licensed physician.

NAD+, explained

The molecule your mitochondria need.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell of your body. It's the molecule your mitochondria use to convert nutrients into ATP — the actual energy currency that powers everything from heartbeat to thought.

NAD+ levels drop ~50% between age 30 and 50. The consequences cascade: fatigue, slower recovery, dimmer cognition, reduced metabolic flexibility, accelerated cellular aging.

Daily subcutaneous injection. Pharmaceutical-grade NAD+ delivered directly under the skin — fastest onset, highest absorption, most reliable serum levels.

The injection is small (insulin-syringe size), virtually painless, and takes seconds to administer at home each morning.

Anyone over 35 who's noticed their baseline energy isn't what it used to be — afternoon crashes, slower recovery, "fog" that wasn't there before. Also patients pursuing longevity protocols who want mitochondrial support alongside other interventions.

NAD+ pairs naturally with TRT, HRT, and sermorelin — addressing the cellular layer that hormones and peptides depend on.

NAD+ is one of the most-studied molecules in longevity research. Documented effects include improved mitochondrial respiration, sirtuin activation, DNA repair, and metabolic flexibility. Clinical NAD+ supplementation has shown improvements in fatigue, sleep, and recovery markers in adult populations.

Sources: Verdin E, Science, 2015. Yoshino J et al, Cell Metabolism, 2018. Martens CR et al, Nature Communications, 2018.

Stacks well with

NAD+ pairs with every protocol.

Hormones and peptides give your body the signals. NAD+ gives it the substrate, and is commonly added alongside these protocols to support the cellular layer. Individual results vary.

Compounded testosterone cypionate vial TRT Testosterone cypionate for men with documented low testosterone. $199/month Explore TRT → Compounded estradiol HRT for women Bioidentical estradiol and progesterone, prescribed together. From $138/month Explore HRT → Compounded sermorelin vial Sermorelin GHRH peptide for sleep depth and daily recovery. $189/month Explore sermorelin →
What you get

Everything in your NAD+ kit

No surprises, no upsells. Each shipment includes everything you need to administer safely at home, plus full clinical support.

OPTML NAD+ kit: alcohol prep pad, vial, and pre-paired syringe
NAD+ subcutaneous injection
Pharmaceutical-grade NAD+ delivered as a daily subcutaneous injection. Fastest onset, highest absorption.
Sterile syringes & needles
Pre-paired insulin syringes sized for subcutaneous injection.
Alcohol pads + sharps bin
Everything for safe, sanitary self-administration at home.
Direct provider access
Call or text your U.S.-licensed provider for dose adjustments and questions.
Free discreet shipping
Insulated, temperature-controlled, plain packaging. Always free.

What the science actually shows

NAD+ is among the most-studied molecules in longevity science. The numbers below reflect documented effects in human supplementation studies and adult mitochondrial-function literature.

↑ ATP
Mitochondrial respiration + cellular ATP output
↑ Sirt
Sirtuin activation (DNA repair, longevity pathways)
Energy
Sustained baseline energy + reduced fatigue

Sources: Verdin E, Science, 2015. Yoshino J et al, Cell Metabolism, 2018. Martens CR et al, Nature Communications, 2018. Effects vary by individual.

Customer reviewing her OPTML protocol on her phone
How it works

Start NAD+ in 4 simple steps.

Online assessment to your door, with free discreet shipping. No in-person visits, no waiting rooms.

Get started →
01

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.

02

Provider evaluation

A U.S.-licensed provider reviews your intake and prescribes the right protocol, if appropriate.

03

Personalized plan

Compounded NAD+, syringes, and supplies. Free discreet shipping. Protocol tailored to your goals.

04

Ongoing support

Message your provider anytime. Dose adjustments, refills, and questions handled in-app.

9:41

Question 1 of 12

What do you want to accomplish with OPTML?

  • Lose weight
  • Energy & vitality
  • Cellular energy & longevity
  • Optimize hormones

 Start NAD+ in 4 simple steps

  1. Start your online visit

    Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.

  2. Provider evaluation

  3. Personalized plan

  4. Ongoing support

Get started →

No commitment. No insurance needed. See full eligibility & contraindications →

What customers across our provider network are saying

Transparent pricing. No surprises.

NAD+, provider oversight via call or text, all supplies, and free shipping included.

Physician-directed care

A U.S.-licensed physician personally reviews every order before anything is prescribed.

  • U.S.-licensed physicians
  • Reviews every order
  • LegitScript Certified
  • 503A pharmacy · USP <797>
Compounded NAD+

One flat price.
Every dose.

Subcutaneous NAD+ prescribed and titrated to your response. Your monthly price stays the same regardless of dose tier.

  • Compounded NAD+ vial
  • Ongoing clinical support
  • Sterile syringes & alcohol prep pads
  • Free discreet shipping
  • Cancel anytime · HSA/FSA eligible
From
$179 /month— cancel anytime

Or $489 every 3 months — flat retail at every dose.

Get started →

Daily subcutaneous, dosed to your response. Patients typically take it in the morning to support the day’s energy curve.

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

Monthly
$179/month— cancel anytime

Billed monthly. Cancel anytime.

  • NAD+ subcutaneous injection
  • Provider oversight via call or text
  • All supplies (syringes, alcohol pads)
  • Free discreet shipping
Start at $179/mo
OPTML High-Performer Protocol: compounded tirzepatide and sermorelin vials
Better Together

The High-Performer Protocol: tirzepatide + sermorelin.

NAD+ supplies the cellular substrate. Tirzepatide and sermorelin supply the signals. The Protocol pairs two medications a physician may prescribe together during medical weight loss to help protect lean mass. NAD+ supports cellular energy alongside both. Individual results vary.

Explore the High-Performer Protocol →

Prescribed by board-certified U.S.-licensed clinicians

Licensed in all 50 states · Meet your care team

After you order

Expected time from order to your door.

Your medication is not sitting on a shelf waiting for you. It is prepared for you, to your prescription, after a physician has read your file — and that is the reason for the wait. Here is where every day goes.

7–10 days
from ordering to it arriving, for a straightforward protocol. Roughly 5–7 days for the physician and the pharmacy, then 2–3 days in transit.
Your online visitabout 10 minutes

Done from your kitchen table, not a waiting room. No appointment to book, no clinic to drive to, no time off work. You answer questions about your health and your goals, and that is the whole of your part in it.

A physician actually reads your filethe slow part, on purpose

A U.S.-licensed physician goes through what you submitted, and your lab work where your protocol calls for it. This is a real clinical decision made by a real person, which is why it takes days rather than minutes — and it is the step you would least want us to rush.

Some protocols need a further conversation, or bloodwork first. TRT, enclomiphene and HRT commonly do.

Your medication is made for younot off a shelf

Once a physician approves it, your prescription goes to a state-licensed, FDA-registered 503A compounding pharmacy, where it is prepared for you individually under USP <797> sterility standards.

That is what compounding means: it is made to your prescription after it is written, rather than manufactured in advance and picked from stock. It is also why this is measured in days. Compounded preparations are not FDA-approved.

It ships to your door2–3 days

Insulated and temperature-controlled, in plain packaging with no medical branding on the outside. Shipping is free and already in your price, and tracking is emailed when it leaves.

The one thing that holds an order upworth reading

An order pauses if something is still outstanding on your side — an intake form you have not finished, ID verification, or lab work. It is the most common reason an order goes quiet, and the system cannot always alert you when it happens.

So if it has been quiet for a couple of days, check your email and your patient portal before anything else. That is nearly always where the missing piece is, and clearing it starts your order moving again immediately. Full checklist here.

Ordering on a Friday or at the weekend

Orders are processed seven days a week. What is not covered at weekends is anything needing a person — a stuck form, an ID check, a question for your provider. Order late on a Friday and you will likely hear more at the start of the week.

How to check where you are

Your patient portal shows the live stage of your order. If your purchase appears there and you have the confirmation email, you are in the queue and nothing is wrong.

These are typical ranges, not guarantees, and delays do happen. Something look wrong? Email info@optml.health and a person will pick it up. For anything clinical, message your physician in the portal. For emergencies, call 911.

NAD+ FAQs

Not exactly. NMN and NR are NAD+ precursors — your body has to convert them. NAD+ subcutaneous injection delivers the molecule directly. Faster onset, higher serum levels, more reliable absorption — at the cost of a prescription requirement and clinical oversight.
Daily subcutaneous injection, taken in the morning to support the day's energy curve. The injection is small (insulin-syringe size) and takes seconds. Split dosing also works for some patients.
Energy and mental clarity often shift within the first 7-14 days. Sleep depth and recovery improvements show in weeks 3-6. Sustained baseline lift compounds over 8-12 weeks as cellular NAD+ pools rebuild.
Common: mild injection-site reactions (transient redness), occasional warm flushing or vivid dreams in first nights. Less common: mild headache or fluid retention. Most resolve within the first 2-4 weeks.

Contraindicated in active malignancy, pregnancy, breastfeeding, or with severe untreated diabetic retinopathy. Full eligibility & contraindications →
Not always required, but a baseline metabolic panel is recommended for patients pursuing comprehensive longevity protocols. The OPTML lab panel is offered as a separate add-on at member rates.
Yes — NAD+ is the most stackable molecule on the menu. It pairs naturally with TRT, HRT, and sermorelin because it supplies the cellular substrate hormones and peptides depend on. Many longevity-minded patients run NAD+ as a continuous baseline protocol.
Insulated, temperature-controlled, plain packaging. Free discreet shipping. Vials arrive pre-mixed and ready to inject, with no reconstitution step. They are stable refrigerated; full storage instructions ship with each kit.
Flat $179/mo for the monthly plan, or $489 every 3 months for the 3-month supply (saves $48 over 3 months). Includes the medication, provider oversight via call or text, all supplies (syringes, needles, alcohol pads), and shipping. Lab panels are a separate add-on at member rates. Cancel anytime.
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Free calculators and quizzes built around real clinical data. Use them as often as you want.

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Important safety information

Sermorelin is a serious medication with real contraindications. Read the full eligibility, side effects, and warnings before starting. Not for use during pregnancy, breastfeeding, or with personal/family history of medullary thyroid carcinoma or MEN-2.

Restore the cellular fuel. Reclaim the energy.

5-minute online consult. Physician review. Free discreet shipping, included in your price.

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Start today

Restore cellular energy.

5-minute online consult. Physician review. Free discreet shipping, included in your price.

  • LegitScript verified
  • Licensed U.S. providers
  • HIPAA-protected
  • 503A pharmacy

Your NAD+ protocol comes with the whole system

  • A physician consultation and ongoing care — reviewed and adjusted by a U.S.-licensed physician, not billed separately.
  • The OPTML 30 — a 30-day starter: mindset, a customizable meal plan, and a gym-or-dumbbell workout.
  • Free tools — daily protein target, TDEE, calorie math, and more.

Included free with your active NAD+ protocol. No separate membership, no add-on charges.

Weight-loss medication disclaimer

OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.

The complete GLP-1 guide

The whole picture in one sitting: who it suits, what the labs decide, what the first year actually looks like. Every clinical claim is cited.

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NAD+ Starting at$179/mo
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