Longevity · Recovery

Is your growth-hormone axis the bottleneck?

A composite score across the four pillars that depend on GH output: sleep depth, recovery, daytime energy, and (optionally) IGF-1. See whether your axis is supporting you, or whether it may need support.

~2 minutes No labs required Optional IGF-1 input
~70%
Of daily GH is released during deep sleep
After 30
GH output declines roughly 1-2% per year
4 signals
Sleep, recovery, energy, and IGF-1

Profile inputs

yrs
hrs
ng/mL

Fill in your profile to see a GH-axis score across sleep, recovery, energy, and (optionally) IGF-1.

A low score is a signal that your GH axis may be worth discussing with a physician.

Score interpretation

Where your score lands, and what it means.

Score range is 0-30. The bands aren’t diagnostic, they’re a structured way to think about whether the GH axis is the right intervention to consider.

25-30
Strong axis

Sleep, recovery, and energy are working. GH-axis support unlikely to add much. Focus on lifestyle compounding.

18-24
Moderate

Some pillars are slipping. Start with lifestyle, sleep, training, and recovery. Worth a physician conversation if symptoms persist.

10-17
Suboptimal

Multiple pillars compromised. Worth discussing with a physician alongside sleep and lifestyle work.

0-9
Severely under-supported

Sleep, energy, and related markers appear under-served. Worth a physician conversation about your GH axis; a baseline IGF-1 lab helps clarify the picture. Individual results vary.

The lifetime view

Your GH axis, across a lifetime.

Growth-hormone output peaks in your late teens and declines steadily, roughly 1-2% a year after 30. Drag the slider to see how much the axis shifts with age, then calculate your score above to plot where your own pillars land.

40
At 40, average GH output is about 63% of its late-teen peak.
The four pillars

What this score actually measures.

Growth hormone is hard to measure directly, serum GH is pulsatile and unreliable. The downstream tissue-level effects are the practical signal.

Sleep depth

The most consistent GH signal

The vast majority of GH release happens in deep (stages 3-4) sleep. Patients with low GH output almost universally report poor sleep depth, frequent wake-ups, and feeling unrested. Sleep depth is usually the first pillar to slip as the GH axis declines.

Daily recovery

Tissue repair speed

Growth hormone plays a role in tendon, ligament, and connective-tissue repair. Slow recovery from normal daily activity and recurring soft-tissue issues can be signs of age-related GH-axis decline in adults over 40. This pillar reflects clinical assessment for documented decline.

Daytime energy

Energy & recovery capacity

The GH axis supports daytime energy, recovery, and sleep-driven restoration. The classic “adult GH-axis decline” pattern is lower energy, slower recovery, and lighter sleep. Under-supported axes drift toward this picture.

IGF-1 (optional)

The downstream lab marker

IGF-1 is the longer-acting messenger that mediates most of GH’s peripheral effects. Low IGF-1 (under ~150 ng/mL in adults) corroborates a low-GH picture; high values suggest your axis is working. Add it if you have a recent value.

How the GH axis works, and why it fades

Growth hormone is released in pulses, mostly during deep, slow-wave sleep. Your pituitary sends the signal, your liver responds by producing IGF-1, and that downstream marker is what a blood test actually measures. It’s the system behind overnight tissue repair, recovery, and how rested you feel the next day.

Output peaks in your late teens and then declines steadily, roughly 1-2% per year after age 30. By your 40s and 50s, total daily GH can be a fraction of what it once was, which is part of why sleep feels lighter and recovery takes longer even when nothing else has changed.

What actually moves it

When lifestyle isn’t enough and labs support it, there are physician-guided approaches that work upstream, encouraging your own pituitary to release GH rather than replacing the hormone directly. Whether any of that is appropriate for you is a decision a U.S.-licensed physician makes after reviewing your history and labs.

This score is not a diagnosis. A low score is a signal that the GH axis may be worth investigating. A physician will typically order a baseline IGF-1 alongside fasting glucose, A1c, and a metabolic panel before deciding whether any support is appropriate.

Your axis is worth understanding.

A low score is a signal, not a diagnosis. A U.S.-licensed physician can review your sleep, recovery, energy, and IGF-1 and decide whether GH-axis support is appropriate for you.

Find my protocol →
References

The science behind the numbers.

This is a structured, educational way to think about the growth-hormone axis using downstream signals like sleep and recovery. The bands are not diagnostic; GH status is assessed by a clinician. It is not medical advice.

Educational purposes only. The GH Optimization Score provides educational estimates based on published clinical formulas and peer-reviewed research. It is not medical advice, does not constitute a prescription, and is not a substitute for evaluation by a licensed clinician. All medical decisions, including any treatment, medication, or dosing recommendations, are made exclusively by a U.S. licensed physician after individual patient evaluation through OPTML's intake process.
Methodology & Sources Click here for the formulas, datasets, and peer-reviewed studies behind this tool View details ↓Hide ↑

How this tool calculates

Peer-reviewed sources

  1. 2.Bidlingmaier M, Friedrich N, Emeny RT, et al. Reference intervals for insulin-like growth factor-1 (IGF-I) from healthy adults: results from the Berlin Aging Study II. the clinical literature 2014;99(5):1712-1721.
  2. 3.Yuen KCJ, Biller BMK, Radovick S, et al. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care. Endocr Pract. 2019;25(11):1191-1232.

Important. This tool is provided for educational purposes only and does not constitute medical advice, diagnosis, or treatment. The tool does not prescribe medication, recommend specific dosing, or substitute for clinical evaluation. Compounded medications referenced anywhere on this site are not FDA-approved; the FDA does not verify the safety, effectiveness, or quality of compounded drugs. Treatment decisions are made only by a licensed U.S. physician after individual patient evaluation.

Weight-loss medication disclaimer

OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.

The complete GLP-1 guide

The whole picture in one sitting: who it suits, what the labs decide, what the first year actually looks like. Every clinical claim is cited.

Free guide

Unlock the free
guide to keeping muscle

How to protect lean mass while losing weight on a GLP-1.

Double-check your email. A typo means we cannot reach you or resend your guide.

We will send occasional emails you can unsubscribe from at any time. See our Privacy Policy.