Sub-clinical GLP-1 for metabolic optimization

The metabolic upside of GLP-1 — without the appetite shut-down.

Sub-clinical doses of compounded semaglutide or tirzepatide for the metabolic and anti-inflammatory benefits of GLP-1 activation — without the heavy appetite shut-down or weight loss of a full-dose protocol.

  • Improved insulin sensitivity + inflammation markers
  • Quieter food noise without the appetite shut-down
  • Free discreet shipping
  • Free provider consult · cancel anytime

Includes a consultation with a U.S.-licensed physician

Compounded medication is not FDA-approved. Sema $199/mo · Tirz $299/mo · HSA/FSA eligible.

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OPTML compounded microdose vial Prescription only 4.9 · 200,000+ patients across our provider network
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Metabolic optimization · Sub-clinical
★★★★★4.9 · 200,000+ patients across our provider network

The metabolic upside of GLP-1 — without the appetite shut-down.

Licensed US providers Free discreet shipping Cancel anytime

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Microdose GLP-1 protocols use sub-therapeutic doses of compounded semaglutide or tirzepatide — typically a fraction of the doses studied in pivotal weight-loss trials. The goal is metabolic optimization (insulin sensitivity, anti-inflammation, gentle appetite calibration), not significant weight loss. Prescribed by U.S.-licensed providers and dispensed by our licensed 503A pharmacy partners.

Compounded preparations are not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. Sub-clinical (off-label) dosing is at provider discretion. Individual results vary.

  • Anti-inflammation + insulin sensitivity
  • Minimal GI effects
  • Provider-titrated
  • Cancel anytime

Sema $199/mo · Tirz $299/mo · Same retail as full-dose · HSA/FSA eligible

88%

of U.S. adults aren't hitting optimal levels across the five markers of metabolic health.

Insulin efficiency Efficient
Blood sugar control (A1c) Steady
Inflammation (hs-CRP) In range
Food noise & cravings Quiet
Cardiovascular markers (ApoB) Balanced

Source: Araujo J, Cai J, Stevens J. "Prevalence of Optimal Metabolic Health in American Adults." Metabolic Syndrome and Related Disorders, 2019 (NHANES 2009–2016). The five markers in the cited study are blood glucose, triglycerides, HDL cholesterol, blood pressure, and waist circumference. Bar positions above are illustrative of the concept of optimization, not a measurement of any individual, not a prediction, and not a claim about any medication or treatment. Whether any marker is appropriate for you is determined by a licensed physician. Compounded medications are not FDA-approved.

Microdose GLP-1, explained

The metabolic upside, without the trade-off.

Microdose GLP-1 means using sub-clinical doses of compounded semaglutide or tirzepatide — well below the doses commonly used in physician-supervised weight-management protocols. The goal isn't significant weight loss. The goal is the metabolic and anti-inflammatory effects of GLP-1 receptor activation: insulin sensitivity, appetite regulation, metabolic flexibility. Compounded medications are not FDA-approved.

For adults focused on metabolic optimization — not patients with significant weight to lose.

Full-dose GLP-1 protocols are titrated to maximum tolerated dose for maximum weight loss. They produce intense appetite suppression that's hard to navigate if you need to eat enough to fuel training and recovery.

Microdose protocols use ~10-25% of full-dose to capture the metabolic upside while leaving your appetite mostly intact.

Microdose semaglutide ($199/mo): single GLP-1 receptor activation, gentlest profile, longest safety record. Best entry point for most optimization-focused patients.

Microdose tirzepatide ($299/mo): dual GIP + GLP-1 receptor activation, metabolic effects often more pronounced even at sub-clinical doses. Best for patients who want maximum metabolic flexibility.

Same retail as full-dose — we charge by molecule, not by milligram.

GLP-1 receptor activation has documented anti-inflammatory and insulin-sensitizing effects independent of weight loss. Sub-clinical dosing is an emerging clinical pattern in optimization medicine — there's strong mechanistic basis but fewer large-scale microdose-specific RCTs than full-dose.

Recent literature documents GLP-1 receptor agonist effects on visceral inflammation, cardiovascular markers, and metabolic flexibility at lower doses. Source: Drucker DJ, Cell Metabolism, 2018.

Microdose vs full-dose

Two different approaches to the same category, for two different goals. Here is how they compare in structure, not in promised results.

Microdose
10–25%
of a full titration
Full-dose
100%
of a full titration
Typical goal
Metabolic optimization
Larger weight change
Approach
Low, steady fraction
Full climbing titration
Often explored by
People optimizing from a lean baseline
People with more to lose
Oversight
Physician-directed
Physician-directed
Sema, monthly
$199/mo
$249/mo
Tirz, monthly
$299/mo
$349/mo

Both approaches are directed by a U.S. licensed physician, who determines which, if either, is appropriate for you, along with your individual dose and schedule.

What you get

Everything in your semaglutide kit

No surprises, no upsells. Each shipment includes everything you need to administer safely at home, plus full clinical support.

OPTML compounded semaglutide kit: alcohol prep pad, vial, and pre-paired syringe
Compounded semaglutide
Sterile, multi-dose vials. Personalized and titrated by your provider.
Sterile syringes & needles
Pre-paired insulin syringes sized for subcutaneous injection.
Alcohol pads + sharps bin
Everything for safe, sanitary self-administration at home.
Provider + care messaging
U.S.-licensed provider review and ongoing clinical support.
Free discreet shipping
Insulated, temperature-controlled, plain packaging. Always free.
Customer reviewing her OPTML protocol on her phone
How it works

Start your microdose GLP-1 in 4 simple steps.

Online assessment to your door, with free discreet shipping. No in-person visits, no waiting rooms.

Get started →
01

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.

02

Provider evaluation

A U.S.-licensed provider reviews your intake and prescribes the right protocol, if appropriate.

03

Personalized plan

Compounded microdose GLP-1, syringes, and supplies. Free discreet shipping. Microdose tailored to you.

04

Ongoing support

Message your provider anytime. Dose adjustments, refills, and questions handled in-app.

9:41

Question 1 of 12

What do you want to accomplish with OPTML?

  • Lose weight
  • Metabolic optimization
  • Energy & vitality
  • Optimize hormones

 Start microdose GLP-1 in 4 simple steps

  1. Start your online visit

    Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.

  2. Provider evaluation

  3. Personalized plan

  4. Ongoing support

Get started →

No commitment. No insurance needed. See full eligibility & contraindications →

Choose your microdose protocol.

Provider consult, compounded medication, and supplies, all included. Cancel anytime.

Physician-directed care

A U.S.-licensed physician personally reviews every order before anything is prescribed.

  • U.S.-licensed physicians
  • Reviews every order
  • LegitScript Certified
  • 503A pharmacy · USP <797>
Compounded microdose GLP-1

One flat price.
Every dose.

Provider-titrated microdose protocol of either compounded semaglutide or tirzepatide. Your monthly price stays the same as your dose evolves — same retail as full-dose, just dosed sub-clinically.

  • Compounded semaglutide or tirzepatide vial
  • Ongoing clinical support
  • Sterile syringes & alcohol prep pads
  • Free discreet shipping
  • Cancel anytime · HSA/FSA eligible
From
$199 /month— cancel anytime

Microdose semaglutide. Tirzepatide $299/mo — same flat retail as full-dose.

Get started →

Provider titrates your microdose protocol based on your response. Microdosing is used to support insulin sensitivity and steadier appetite signals. Individual results vary.

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

Microdose Semaglutide
$249/month— cancel anytime

Billed monthly. Cancel anytime.

  • Compounded semaglutide (microdose)
  • Provider consultation
  • Syringes & supplies
  • Free discreet shipping
  • Provider messaging
Start at $199/mo
OPTML High-Performer Protocol: compounded semaglutide and sermorelin vials
Ready for more · Premium tier

When you're ready to graduate from semaglutide.

Many semaglutide patients move up to the High-Performer Protocol — tirzepatide + sermorelin — once they've adjusted to GLP-1 therapy. Stronger fat loss, plus sleep and recovery support. The premium protocol when you want comprehensive care.

Explore the High-Performer Protocol →

Prescribed by board-certified U.S.-licensed clinicians

Licensed in all 50 states · Meet your care team

After you order

Expected time from order to your door.

Your medication is not sitting on a shelf waiting for you. It is prepared for you, to your prescription, after a physician has read your file — and that is the reason for the wait. Here is where every day goes.

7–10 days
from ordering to it arriving, for a straightforward protocol. Roughly 5–7 days for the physician and the pharmacy, then 2–3 days in transit.
Your online visitabout 10 minutes

Done from your kitchen table, not a waiting room. No appointment to book, no clinic to drive to, no time off work. You answer questions about your health and your goals, and that is the whole of your part in it.

A physician actually reads your filethe slow part, on purpose

A U.S.-licensed physician goes through what you submitted, and your lab work where your protocol calls for it. This is a real clinical decision made by a real person, which is why it takes days rather than minutes — and it is the step you would least want us to rush.

Some protocols need a further conversation, or bloodwork first. TRT, enclomiphene and HRT commonly do.

Your medication is made for younot off a shelf

Once a physician approves it, your prescription goes to a state-licensed, FDA-registered 503A compounding pharmacy, where it is prepared for you individually under USP <797> sterility standards.

That is what compounding means: it is made to your prescription after it is written, rather than manufactured in advance and picked from stock. It is also why this is measured in days. Compounded preparations are not FDA-approved.

It ships to your door2–3 days

Insulated and temperature-controlled, in plain packaging with no medical branding on the outside. Shipping is free and already in your price, and tracking is emailed when it leaves.

The one thing that holds an order upworth reading

An order pauses if something is still outstanding on your side — an intake form you have not finished, ID verification, or lab work. It is the most common reason an order goes quiet, and the system cannot always alert you when it happens.

So if it has been quiet for a couple of days, check your email and your patient portal before anything else. That is nearly always where the missing piece is, and clearing it starts your order moving again immediately. Full checklist here.

Ordering on a Friday or at the weekend

Orders are processed seven days a week. What is not covered at weekends is anything needing a person — a stuck form, an ID check, a question for your provider. Order late on a Friday and you will likely hear more at the start of the week.

How to check where you are

Your patient portal shows the live stage of your order. If your purchase appears there and you have the confirmation email, you are in the queue and nothing is wrong.

These are typical ranges, not guarantees, and delays do happen. Something look wrong? Email info@optml.health and a person will pick it up. For anything clinical, message your physician in the portal. For emergencies, call 911.

Microdose FAQs

Maybe a little, but it's not the goal. A modest weight shift is sometimes observed as a side effect of improved metabolic health; individual results vary. If significant weight loss is your priority, microdose isn't the right protocol — you want full-dose semaglutide or tirzepatide.
No. OPTML pricing is by molecule, not by milligram. Compounded semaglutide is $249/mo and compounded tirzepatide is $299/mo whether you're on a microdose or a full clinical titration. Transparent flat retail.
Most patients start with sema microdose: gentlest profile, longest safety record, $199/mo. Tirz microdose ($299/mo) makes sense if you've already responded well to GLP-1 therapy and want the dual-receptor metabolic effect at a sub-clinical dose. Your provider helps you decide.
Microdose protocols dramatically reduce GI side effects vs full-dose; nausea and appetite changes are uncommon. Occasional mild fatigue or transient injection-site irritation in the first 1-2 weeks. Full GLP-1 eligibility & contraindications →
Not always required, but a baseline metabolic panel (insulin, A1C, lipid panel, hs-CRP) gives your provider a starting point and lets you actually track the metabolic improvements you're after. The OPTML lab panel is offered as a separate add-on at member rates.
Yes — microdose pairs well with TRT, HRT, sermorelin, and NAD+. The metabolic and anti-inflammatory benefits of microdose GLP-1 amplify the rest of an optimization protocol.
Insulated, temperature-controlled, plain packaging. Free discreet shipping. Vials are stable refrigerated; full storage and dosing instructions ship with each kit.
Sema microdose: $199/mo. Tirz microdose: $299/mo. Same retail as full-dose — we charge by molecule, not by milligram. All-inclusive: medication, provider oversight via call or text, supplies, and shipping. Lab panels are a separate add-on at member rates. Cancel anytime.
15 free tools

Learn more about hitting your goals

Free calculators and quizzes built around real clinical data. Use them as often as you want.

Complete guide

The complete GLP-1 guide

Read

Goal date

When will you hit your goal weight?

Calculate

BMI

BMI & eligibility check

Calculate

Match quiz

Find my protocol — match in 90 seconds

Take quiz

Deficit

Daily calorie deficit for your goal

Calculate

TDEE

Total daily energy expenditure

Calculate

BMR

Basal metabolic rate

Calculate

Protein

Daily protein target for your goal

Calculate
View all 15 tools

Important safety information

Semaglutide is a serious medication with real contraindications. Read the full eligibility, side effects, and warnings before starting. Not for use during pregnancy, breastfeeding, or with personal/family history of medullary thyroid carcinoma or MEN-2.

The metabolic upside. Without the trade-off.

5-minute online consult. Physician review. Free discreet shipping, included in your price.

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LegitScript verifiedLicensed US providersHIPAA-protected503A pharmacy
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Start today

The metabolic upside. Without the trade-off.

5-minute online consult. Physician review. Free discreet shipping, included in your price.

  • LegitScript verified
  • Licensed U.S. providers
  • HIPAA-protected
  • 503A pharmacy

Your microdose protocol comes with the whole system

  • A physician consultation and ongoing care — reviewed and adjusted by a U.S.-licensed physician, not billed separately.
  • The OPTML 30 — a 30-day starter: mindset, a customizable meal plan, and a gym-or-dumbbell workout.
  • GLP-1 Muscle Loss Protocol — an educational guide to preserving muscle during medically supervised weight loss. Read what the research says. What your GLP-1 year looks like.
  • Your GLP-1 field guides — side-effect playbook and what to expect, week by week.
  • Free tools — daily protein target, TDEE, calorie math, and more.

Included free with your active microdose protocol. No separate membership, no add-on charges.

Weight-loss medication disclaimer

OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.

The complete GLP-1 guide

The whole picture in one sitting: who it suits, what the labs decide, what the first year actually looks like. Every clinical claim is cited.

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Microdose GLP-1 Starting at$199/mo
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