Sub-clinical doses of compounded semaglutide or tirzepatide for the metabolic and anti-inflammatory benefits of GLP-1 activation — without the heavy appetite shut-down or weight loss of a full-dose protocol.
Includes a consultation with a U.S.-licensed physician
Compounded medication is not FDA-approved. Sema $199/mo · Tirz $299/mo · HSA/FSA eligible.
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Microdose GLP-1 protocols use sub-therapeutic doses of compounded semaglutide or tirzepatide — typically a fraction of the doses studied in pivotal weight-loss trials. The goal is metabolic optimization (insulin sensitivity, anti-inflammation, gentle appetite calibration), not significant weight loss. Prescribed by U.S.-licensed providers and dispensed by our licensed 503A pharmacy partners.
Compounded preparations are not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. Sub-clinical (off-label) dosing is at provider discretion. Individual results vary.
Sema $199/mo · Tirz $299/mo · Same retail as full-dose · HSA/FSA eligible
of U.S. adults aren't hitting optimal levels across the five markers of metabolic health.
Source: Araujo J, Cai J, Stevens J. "Prevalence of Optimal Metabolic Health in American Adults." Metabolic Syndrome and Related Disorders, 2019 (NHANES 2009–2016). The five markers in the cited study are blood glucose, triglycerides, HDL cholesterol, blood pressure, and waist circumference. Bar positions above are illustrative of the concept of optimization, not a measurement of any individual, not a prediction, and not a claim about any medication or treatment. Whether any marker is appropriate for you is determined by a licensed physician. Compounded medications are not FDA-approved.
Microdose GLP-1 means using sub-clinical doses of compounded semaglutide or tirzepatide — well below the doses commonly used in physician-supervised weight-management protocols. The goal isn't significant weight loss. The goal is the metabolic and anti-inflammatory effects of GLP-1 receptor activation: insulin sensitivity, appetite regulation, metabolic flexibility. Compounded medications are not FDA-approved.
For adults focused on metabolic optimization — not patients with significant weight to lose.
Full-dose GLP-1 protocols are titrated to maximum tolerated dose for maximum weight loss. They produce intense appetite suppression that's hard to navigate if you need to eat enough to fuel training and recovery.
Microdose protocols use ~10-25% of full-dose to capture the metabolic upside while leaving your appetite mostly intact.
Microdose semaglutide ($199/mo): single GLP-1 receptor activation, gentlest profile, longest safety record. Best entry point for most optimization-focused patients.
Microdose tirzepatide ($299/mo): dual GIP + GLP-1 receptor activation, metabolic effects often more pronounced even at sub-clinical doses. Best for patients who want maximum metabolic flexibility.
Same retail as full-dose — we charge by molecule, not by milligram.
GLP-1 receptor activation has documented anti-inflammatory and insulin-sensitizing effects independent of weight loss. Sub-clinical dosing is an emerging clinical pattern in optimization medicine — there's strong mechanistic basis but fewer large-scale microdose-specific RCTs than full-dose.
Recent literature documents GLP-1 receptor agonist effects on visceral inflammation, cardiovascular markers, and metabolic flexibility at lower doses. Source: Drucker DJ, Cell Metabolism, 2018.
Two different approaches to the same category, for two different goals. Here is how they compare in structure, not in promised results.
Both approaches are directed by a U.S. licensed physician, who determines which, if either, is appropriate for you, along with your individual dose and schedule.
No surprises, no upsells. Each shipment includes everything you need to administer safely at home, plus full clinical support.
Online assessment to your door, with free discreet shipping. No in-person visits, no waiting rooms.
Get started →Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.
A U.S.-licensed provider reviews your intake and prescribes the right protocol, if appropriate.
Compounded microdose GLP-1, syringes, and supplies. Free discreet shipping. Microdose tailored to you.
Message your provider anytime. Dose adjustments, refills, and questions handled in-app.
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Start microdose GLP-1 in 4 simple steps
Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.
No commitment. No insurance needed. See full eligibility & contraindications →
Provider consult, compounded medication, and supplies, all included. Cancel anytime.
A U.S.-licensed physician personally reviews every order before anything is prescribed.
Provider-titrated microdose protocol of either compounded semaglutide or tirzepatide. Your monthly price stays the same as your dose evolves — same retail as full-dose, just dosed sub-clinically.
Microdose semaglutide. Tirzepatide $299/mo — same flat retail as full-dose.
Provider titrates your microdose protocol based on your response. Microdosing is used to support insulin sensitivity and steadier appetite signals. Individual results vary.
Your monthly price includes everything.
Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.
Billed monthly. Cancel anytime.
Billed monthly. Cancel anytime.
Prescribed by board-certified U.S.-licensed clinicians
Licensed in all 50 states · Meet your care team
Your medication is not sitting on a shelf waiting for you. It is prepared for you, to your prescription, after a physician has read your file — and that is the reason for the wait. Here is where every day goes.
Done from your kitchen table, not a waiting room. No appointment to book, no clinic to drive to, no time off work. You answer questions about your health and your goals, and that is the whole of your part in it.
A U.S.-licensed physician goes through what you submitted, and your lab work where your protocol calls for it. This is a real clinical decision made by a real person, which is why it takes days rather than minutes — and it is the step you would least want us to rush.
Some protocols need a further conversation, or bloodwork first. TRT, enclomiphene and HRT commonly do.
Once a physician approves it, your prescription goes to a state-licensed, FDA-registered 503A compounding pharmacy, where it is prepared for you individually under USP <797> sterility standards.
That is what compounding means: it is made to your prescription after it is written, rather than manufactured in advance and picked from stock. It is also why this is measured in days. Compounded preparations are not FDA-approved.
Insulated and temperature-controlled, in plain packaging with no medical branding on the outside. Shipping is free and already in your price, and tracking is emailed when it leaves.
An order pauses if something is still outstanding on your side — an intake form you have not finished, ID verification, or lab work. It is the most common reason an order goes quiet, and the system cannot always alert you when it happens.
So if it has been quiet for a couple of days, check your email and your patient portal before anything else. That is nearly always where the missing piece is, and clearing it starts your order moving again immediately. Full checklist here.
Orders are processed seven days a week. What is not covered at weekends is anything needing a person — a stuck form, an ID check, a question for your provider. Order late on a Friday and you will likely hear more at the start of the week.
Your patient portal shows the live stage of your order. If your purchase appears there and you have the confirmation email, you are in the queue and nothing is wrong.
These are typical ranges, not guarantees, and delays do happen. Something look wrong? Email info@optml.health and a person will pick it up. For anything clinical, message your physician in the portal. For emergencies, call 911.
Free calculators and quizzes built around real clinical data. Use them as often as you want.
Complete guide
The complete GLP-1 guide
Goal date
When will you hit your goal weight?
BMI
BMI & eligibility check
Match quiz
Find my protocol — match in 90 seconds
Deficit
Daily calorie deficit for your goal
TDEE
Total daily energy expenditure
BMR
Basal metabolic rate
Protein
Daily protein target for your goal
5-minute online consult. Physician review. Free discreet shipping, included in your price.
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5-minute online consult. Physician review. Free discreet shipping, included in your price.
Your microdose protocol comes with the whole system
Included free with your active microdose protocol. No separate membership, no add-on charges.
OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.
The whole picture in one sitting: who it suits, what the labs decide, what the first year actually looks like. Every clinical claim is cited.
How to protect lean mass while losing weight on a GLP-1.
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