How much does The Longevity Protocol cost?

$348 per month, billed monthly, cancel anytime. Or $988 every three months (a single quarterly shipment). Pricing is the same in every state. HSA/FSA eligible. No insurance is involved.

Can I cancel anytime?

Yes. Both monthly and 3-month plans can be canceled or paused anytime. No contracts. Your monthly price includes physician consultation, prescription, and ongoing medical oversight.

The Longevity Protocol — NAD+ & Sermorelin, Together

Name: The Longevity Protocol — Compounded NAD+ and Sermorelin via OPTML
Brand: OPTML
Price: 299 USD
Availability: MadeToOrder

One protocol, one shipment

Two compounded medications, one physician, one monthly price.

Compounded protocols under one physician-led plan

Monthly shipment. Discreet, temperature-controlled where needed

U.S. states where the protocol is available

Week recheck recommended with baseline labs

What’s in the stack

Two compounded preparations. One nightly window.

Each medication is prepared by an FDA-registered 503A pharmacy and dispensed under your provider’s prescription. Compounded preparations are not FDA-approved.

OPTML Longevity Protocol kit: compounded sermorelin and NAD+ vials, sterile syringe and alcohol prep pad

Cellular co-factor

Compounded NAD+

Subcutaneous nicotinamide adenine dinucleotide. NAD+ is the co-factor that hundreds of cellular enzymes rely on to convert nutrients to energy and to drive DNA repair pathways. Levels decline with age in published research.

Form

Subcutaneous injection

Cadence

Weekly

GH-axis support

Compounded Sermorelin

A GHRH analog that signals the pituitary to release pulses of the body’s own growth hormone. Used in clinical contexts for documented age-related GH-axis decline. Dosed at bedtime to match the body’s natural release window.

Form

Subcutaneous injection

Cadence

Nightly at bedtime

Who this is for

Built for adults who’ve already done the basics.

The Longevity Protocol is reviewed and prescribed by a U.S.-licensed physician based on your intake, history, and (in most cases) baseline labs. It’s not for everyone — here’s where it tends to fit.

Adults 35-65 whose sleep, recovery, and energy have plateaued.

You’ve dialed in nutrition, training, and bloodwork basics. Your day-to-day recovery and sleep depth have quietly declined over a few years, and you want a physician-supervised next step.

Patients with documented age-related GH-axis decline.

If your provider has reviewed baseline labs (including IGF-1) and confirmed a decline consistent with age, a sermorelin-based protocol can be part of a longitudinal plan. Lab work is strongly recommended before starting.

People who want a single physician-led longevity protocol, not a stack of supplements.

One intake, one provider, one monthly shipment, one place to call. Both medications are compounded and prescribed under the same plan, so titration and follow-up are coordinated.

OPTML prescribes NAD+ and sermorelin only under clinical indications reviewed by a U.S.-licensed physician. We do not prescribe for athletic performance, bodybuilding, or aesthetic purposes. Compounded preparations are not FDA-approved.

Mechanism reference · scroll to see the shift

Watch the same six systems go from declining to restored.

Between ages 30 and 60, cellular NAD⁺ drops ~50% and the endogenous GH-axis pulse amplitude attenuates. Keep scrolling — watch the six systems the protocol is designed to address shift from red (age-related baseline) to green (mechanism target).

Cellular NAD⁺ availability NAD⁺ Restored

Mitochondrial ATP production NAD⁺ Supported

GH-axis pulse amplitude Sermorelin Reinforced

Slow-wave sleep depth Sermorelin Deeper

DNA-repair signaling (PARP / sirtuin) NAD⁺ Active

GH-axis & recovery signaling Sermorelin Supported

Mechanism reference. The six systems above describe targets the protocol is designed to address, drawn from published research on NAD⁺ co-factor availability (Verdin, Science, 2015; Yoshino, Cell Metab, 2018) and GHRH-axis support (Vitiello, Sleep, 2006; Khorram, 1997). Compounded NAD⁺ and compounded sermorelin are not FDA-approved; the FDA does not verify the safety, effectiveness, or quality of compounded drugs. Not a prediction of personal outcomes. Individual response varies.

Peer-reviewed reference library

11 studies the protocol draws from.

Tap a topic to expand its peer-reviewed citations with direct PubMed links.

01NAD⁺ & cellular energy metabolism4 studies

Verdin E. NAD⁺ in aging, metabolism, and neurodegeneration. Science, 2015. PubMed 26785480 →
Yoshino J et al. NAD⁺ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metabolism, 2018. PubMed 29249689 →
Rajman L et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism, 2018. PubMed 29562503 →
Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD⁺ and sirtuin-activating compounds. Nat Rev Mol Cell Biol, 2016. PubMed 27552971 →

02NAD⁺, sirtuins & PARP-mediated DNA repair2 studies

Imai S, Guarente L. NAD⁺ and sirtuins in aging and disease. Trends in Cell Biology, 2014. PubMed 24786309 →
Sorrentino V et al. Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity. Nature, 2017. PubMed 29211722 →

03Sermorelin & the endogenous GH-axis3 studies

Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Endocrine, 2006. PubMed 17075238 →
Khorram O et al. Effects of growth-hormone-releasing hormone on lean body mass and other clinical variables in older men and women. 1997. PubMed 9112674 →
Murphy MG et al. MK-677, an orally active GHRH-mimetic, restores the GH/IGF-I axis in older adults. 1998. PubMed 9482839 →

04GHRH-class compounds & slow-wave sleep1 study

Vitiello MV et al. Growth hormone-releasing hormone improves cognition and slow-wave sleep in older adults. Sleep, 2006. PubMed 16453978 →

05Age-related decline in the GH-axis1 study

Sinha I, Sinha-Hikim AP et al. Decline in growth hormone secretion with age and its consequences. 2014 review. PubMed 25181281 →

All references are peer-reviewed and indexed on PubMed.gov. Educational reference only. Compounded preparations are not FDA-approved. The citations describe published research on NAD⁺ and GHRH-class compounds; they do not predict individual results.

How it works

Three steps. No insurance. No phone tag.

STEP 01

Take the 60-second quiz

A ~5-minute online assessment covering history, goals, current medications, and baseline lab access. You upload existing labs if you have them.

STEP 02

Physician review

A U.S.-licensed physician reviews your intake. They may order baseline labs (IGF-1, A1C, lipid panel, inflammatory markers) before approving a protocol. The Apex Panel covers all of these in one draw.

STEP 03

Monthly shipment

Both compounded medications, all supplies, and provider follow-up via call or message arrive together. Cancel, pause, or change cadence anytime from your patient portal.

Pricing

One price. Everything included.

Medication, physician oversight, supplies, and shipping all in. No insurance, no hidden fees, cancel anytime.

Physician-directed care

A U.S.-licensed physician personally reviews every order before anything is prescribed.

U.S.-licensed physicians
Reviews every order
LegitScript Certified
503A pharmacy · USP <797>

Monthly

$348/month

Billed monthly. Cancel anytime. HSA/FSA eligible.

Start monthly

Best Value

3-month supply

$988/3 monthsSave $56

One quarterly shipment. Cancel anytime. HSA/FSA eligible.

Start 3-month

Your monthly price includes everything. Both compounded medications, physician consultation, prescription, all supplies, and ongoing oversight. No hidden fees. No separate membership. Cancel anytime.

After you order

Expected time from order to your door.

Your medication is not sitting on a shelf waiting for you. It is prepared for you, to your prescription, after a physician has read your file — and that is the reason for the wait. Here is where every day goes.

7–10 days

from ordering to it arriving, for a straightforward protocol. Roughly 5–7 days for the physician and the pharmacy, then 2–3 days in transit.

Your online visitabout 10 minutes

Done from your kitchen table, not a waiting room. No appointment to book, no clinic to drive to, no time off work. You answer questions about your health and your goals, and that is the whole of your part in it.

A physician actually reads your filethe slow part, on purpose

A U.S.-licensed physician goes through what you submitted, and your lab work where your protocol calls for it. This is a real clinical decision made by a real person, which is why it takes days rather than minutes — and it is the step you would least want us to rush.

Some protocols need a further conversation, or bloodwork first. TRT, enclomiphene and HRT commonly do.

Your medication is made for younot off a shelf

Once a physician approves it, your prescription goes to a state-licensed, FDA-registered 503A compounding pharmacy, where it is prepared for you individually under USP <797> sterility standards.

That is what compounding means: it is made to your prescription after it is written, rather than manufactured in advance and picked from stock. It is also why this is measured in days. Compounded preparations are not FDA-approved.

It ships to your door2–3 days

Insulated and temperature-controlled, in plain packaging with no medical branding on the outside. Shipping is free and already in your price, and tracking is emailed when it leaves.

The one thing that holds an order upworth reading

An order pauses if something is still outstanding on your side — an intake form you have not finished, ID verification, or lab work. It is the most common reason an order goes quiet, and the system cannot always alert you when it happens.

So if it has been quiet for a couple of days, check your email and your patient portal before anything else. That is nearly always where the missing piece is, and clearing it starts your order moving again immediately. Full checklist here.

Ordering on a Friday or at the weekend

Orders are processed seven days a week. What is not covered at weekends is anything needing a person — a stuck form, an ID check, a question for your provider. Order late on a Friday and you will likely hear more at the start of the week.

How to check where you are

Your patient portal shows the live stage of your order. If your purchase appears there and you have the confirmation email, you are in the queue and nothing is wrong.

These are typical ranges, not guarantees, and delays do happen. Something look wrong? Email info@optml.health and a person will pick it up. For anything clinical, message your physician in the portal. For emergencies, call 911.

Questions

Frequently asked.

What is The Longevity Protocol?

The Longevity Protocol pairs two compounded protocols — subcutaneous NAD⁺ and sermorelin (a GHRH analog) — under one physician-led plan. The combination is intended to support cellular co-factor availability and the body’s own growth-hormone axis. Always reviewed and prescribed by a licensed U.S. physician. Compounded preparations are not FDA-approved.

Are NAD⁺ and sermorelin FDA-approved?

Compounded NAD⁺ and compounded sermorelin prepared for individual patient prescriptions are not FDA-approved. The FDA does not verify the safety, effectiveness, or quality of compounded drugs. Both compounded preparations dispensed through OPTML are prepared by FDA-registered 503A pharmacies under USP <797> sterility standards.

Who is this protocol prescribed for?

The Longevity Protocol is reviewed by a U.S.-licensed physician for adults with documented age-related GH-axis decline and longevity-oriented goals. OPTML does not prescribe sermorelin or NAD⁺ for athletic performance, bodybuilding, or aesthetic purposes. Baseline labs are strongly recommended before starting.

Do I need lab work first?

Strongly recommended. A baseline panel is advisable, including IGF-1, A1C, lipid markers, and inflammatory markers. The OPTML Apex Panel covers all of these (and many more) in one draw and is the most commonly paired baseline.

How much does it cost?

$348/month, billed monthly, cancel anytime. Or $988 every three months (a single quarterly shipment, save $56 vs paying monthly). Pricing is the same in every state OPTML serves. HSA/FSA eligible. No insurance is involved.

How is it shipped?

Both compounded medications, syringes, alcohol pads, and a sharps container arrive together. Free discreet shipping, included in your price. NAD⁺ ships in temperature-controlled packaging where required. Discreet packaging from our 503A pharmacy partners.

Can I cancel or pause?

Yes. Both monthly and 3-month plans can be canceled or paused anytime from your patient portal. No contracts. Refunds for unshipped medication are issued per OPTML’s standard policy.

Two compounded protocols. One nightly routine.

Two compounded medications, one physician, one monthly price.

Two compounded preparations. One nightly window.

Compounded NAD+

Compounded Sermorelin

Built for adults who’ve already done the basics.

Adults 35-65 whose sleep, recovery, and energy have plateaued.

Patients with documented age-related GH-axis decline.

People who want a single physician-led longevity protocol, not a stack of supplements.

Watch the same six systems go from declining to restored.

11 studies the protocol draws from.

Three steps. No insurance. No phone tag.

Take the 60-second quiz

Physician review

Monthly shipment

One price. Everything included.

What people on the protocol are saying.

Start with a baseline.
The Apex Panel.

Expected time from order to your door.

Frequently asked.

The complete GLP-1 guide

Unlock the free
guide to keeping muscle

Two compounded protocols. One nightly routine.

Two compounded medications, one physician, one monthly price.

Two compounded preparations. One nightly window.

Compounded NAD+

Compounded Sermorelin

Built for adults who’ve already done the basics.

Adults 35-65 whose sleep, recovery, and energy have plateaued.

Patients with documented age-related GH-axis decline.

People who want a single physician-led longevity protocol, not a stack of supplements.

Watch the same six systems go from declining to restored.

11 studies the protocol draws from.

Three steps. No insurance. No phone tag.

Take the 60-second quiz

Physician review

Monthly shipment

One price. Everything included.

What people on the protocol are saying.

Pair the protocol with the right baseline.

Biological Age Calculator

GH-axis Self-Score

Lab Decoder

Find My Protocol

Optimization protocols, compared

Start with a baseline.The Apex Panel.

Expected time from order to your door.

Frequently asked.

The complete GLP-1 guide

Unlock the freeguide to keeping muscle

Start with a baseline.
The Apex Panel.

Unlock the free
guide to keeping muscle