What are the side effects?

Most common: nausea, constipation, diarrhea, fatigue, typically mild and temporary. Side effect profile is similar to semaglutide. Your provider starts you at a low dose and titrates up slowly.

How is compounded tirzepatide prepared?

Compounded tirzepatide is prepared by FDA-registered 503A pharmacies under USP sterility standards, on prescription by a U.S. licensed physician. Compounded medications are not FDA-approved.

Dual GIP/GLP-1 weight-loss molecule

Compounded tirzepatide,
prescribed online.

Tirzepatide is a dual GIP and GLP-1 receptor agonist used in physician-supervised weight-management protocols. The literature describes the dual mechanism as having a stronger appetite-modulation profile than GLP-1 alone. OPTML dispenses compounded tirzepatide on prescription by U.S. licensed physicians; compounded medications are not FDA-approved.

All-inclusive pricing — no membership fees
503A licensed pharmacies (USP <797>)
Free discreet shipping · cancel anytime
Only at OPTML
GLP-1 Muscle Loss Protocol included
Educational guide on muscle preservation during physician-supervised GLP-1 protocols.

Get started How it works →

Includes a consultation with a U.S.-licensed physician

Compounded medication is not FDA-approved. Starting at $349/mo · HSA/FSA eligible.

LegitScript CertifiedHealthcare Merchant

Hand with yellow nails holding OPTML compounded tirzepatide vial

Prescription only 4.9 · 200,000+ patients across our provider network

Weight Loss · Dual GIP/GLP-1

★★★★★4.9 · 200,000+ patients across our provider network

Tirzepatide — the dual-pathway molecule, prescribed and delivered.

✓ Licensed US providers✓ Free discreet shipping✓ Cancel anytime

LegitScript CertifiedHealthcare Merchant

All-inclusive pricing — no membership fees
503A licensed pharmacies (USP <797> standards)
U.S.-licensed providers
Cancel anytime, no contract
Free discreet shipping

Only at OPTML

GLP-1 Muscle Loss Protocol included

Educational guide on muscle preservation during physician-supervised GLP-1 protocols.

Get started How it works

Starting at $349/mo · Free provider consult · HSA/FSA eligible

The Rebound Cycle

80%

Roughly 8 in 10 people who lose weight through dieting alone regain it. Not because they quit. Because their biology fought back.

Wing & Phelan, Am J Clin Nutr 2005 · Sumithran et al., NEJM 2011 · Fothergill et al., Obesity 2016

How many times have you lost 10+ lbs?

Current weight 220lbs

Goal weight 180lbs

Weight you may have lost and regained

100lbs

2.5 cycles × 40 lb gap

The work was real every single time. But the body fights to keep weight on, and that pushback is biology, not a lack of discipline.

You were never the problem.
Your biology was.

And biology is something a U.S. licensed physician can measure and treat. They review your history, run your labs, and determine whether prescription treatment is appropriate for you.

Get started

Where these numbers come from

Long-term studies of dieting consistently find most lost weight is regained within 3 to 5 years (Wing & Phelan, Am J Clin Nutr 2005). After weight loss, ghrelin rises and leptin falls, and these shifts persist for at least a year (Sumithran et al., NEJM 2011). Resting metabolic rate can stay suppressed for years (Fothergill et al., Obesity 2016). Figures describe research populations and dieting in general; they are educational, not a prediction of your results or a claim about any treatment.

Tirzepatide, explained

The most studied molecule in the GLP-1 class.

Tirzepatide is a once-weekly injectable molecule that activates two metabolic receptors, GIP and GLP-1. It is used in physician-supervised weight-management protocols. The literature describes the dual mechanism as having a stronger appetite-modulation profile than GLP-1 alone.

OPTML’s compounded tirzepatide is prescribed by U.S. licensed physicians and prepared by licensed 503A pharmacies under USP <797> sterility standards, then shipped to your door monthly. Compounded medications are not FDA-approved.

Semaglutide activates a single receptor: GLP-1. Tirzepatide activates two: GIP and GLP-1. The literature describes the dual mechanism as having a stronger appetite-modulation profile than GLP-1 alone.

Customer reviewing her OPTML protocol on her phone

How it works

Start tirzepatide in 4 simple steps.

Online assessment to your door, with free discreet shipping. No in-person visits, no waiting rooms.

Get started →

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.

Provider evaluation

A U.S.-licensed provider reviews your intake and prescribes the right protocol, if appropriate.

Personalized plan

Compounded tirzepatide, syringes, and supplies. Free discreet shipping. Titration tailored to you.

Ongoing support

Message your provider anytime. Dose adjustments, refills, and questions handled in-app.

9:41

Question 1 of 12

What do you want to accomplish with OPTML?

Lose weight
Energy & vitality
Optimize hormones
Improve sleep & recovery

Start losing weight in 4 simple steps

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.
Provider evaluation
Personalized plan
Ongoing support

Get started →

No commitment. No insurance needed. See full eligibility & contraindications →

Inside the protocol

$349^/mo

Flat retail at every dose. No hidden tiers.

Compounded tirzepatide

The dual GIP/GLP-1 molecule, compounded by a licensed 503A pharmacy partner. Sterile vials prepared per prescription. Personalized by your provider. Compounded preparation; not FDA-approved.

U.S.-licensed provider

Your prescription is reviewed and managed by a licensed clinician. Your plan is coordinated to your response, not a generic protocol.

Direct provider access

Call or text your provider whenever you need to. Dose adjustments, side-effect questions, refills — handled in-thread.

All injection supplies

Sterile syringes, needles, and alcohol prep pads in every shipment. Sharps container included. No add-on charges, no surprise reorders.

Free discreet shipping

Insulated, temperature-controlled, plain packaging. Always free, always tracked. Refrigerated stability instructions included.

503A-pharmacy compounded

Prepared by FDA-registered 503A pharmacies under USP <797> sterility standards. Every vial traceable, every batch tested.

Lab panels available as a separate add-on at member rates. HSA/FSA eligible. Cancel anytime.

Get started →

Transparent pricing.
No surprises.

One flat monthly price. No tiers, no surprise bills.

Physician-directed care

A U.S.-licensed physician personally reviews every order before anything is prescribed.

U.S.-licensed physicians
Reviews every order
LegitScript Certified
503A pharmacy · USP <797>

Compounded tirzepatide

One flat price.
Every dose.

One price from your first month through your full plan. No tier upgrades, no surcharges as you progress, no surprise bills.

Compounded tirzepatide vial
Ongoing clinical support
Sterile syringes & alcohol prep pads
Free discreet shipping
Cancel anytime · HSA/FSA eligible

From

$349 /month— cancel anytime

Same price at every step of your plan.

Get started →

Your licensed physician personalizes your plan to your response — your monthly price stays exactly the same.

Your monthly price includes everything. Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

Monthly

$349/month— cancel anytime

Billed monthly. Cancel anytime.

Compounded tirzepatide
Provider consultation
Syringes & supplies
Free discreet shipping
Ongoing support

Start at $349/mo

OPTML High-Performer Protocol: compounded tirzepatide and sermorelin vials

Better Together

The High-Performer Protocol: tirzepatide + sermorelin.

GLP-1 for weight loss. GHRH peptide for sleep and recovery. Tirzepatide is commonly paired with sermorelin to support sleep and recovery during weight loss. Individual results vary.

Explore the High-Performer Protocol →

After you order

Expected time from order to your door.

Your medication is not sitting on a shelf waiting for you. It is prepared for you, to your prescription, after a physician has read your file — and that is the reason for the wait. Here is where every day goes.

7–10 days

from ordering to it arriving, for a straightforward protocol. Roughly 5–7 days for the physician and the pharmacy, then 2–3 days in transit.

Your online visitabout 10 minutes

Done from your kitchen table, not a waiting room. No appointment to book, no clinic to drive to, no time off work. You answer questions about your health and your goals, and that is the whole of your part in it.

A physician actually reads your filethe slow part, on purpose

A U.S.-licensed physician goes through what you submitted, and your lab work where your protocol calls for it. This is a real clinical decision made by a real person, which is why it takes days rather than minutes — and it is the step you would least want us to rush.

Some protocols need a further conversation, or bloodwork first. TRT, enclomiphene and HRT commonly do.

Your medication is made for younot off a shelf

Once a physician approves it, your prescription goes to a state-licensed, FDA-registered 503A compounding pharmacy, where it is prepared for you individually under USP <797> sterility standards.

That is what compounding means: it is made to your prescription after it is written, rather than manufactured in advance and picked from stock. It is also why this is measured in days. Compounded preparations are not FDA-approved.

It ships to your door2–3 days

Insulated and temperature-controlled, in plain packaging with no medical branding on the outside. Shipping is free and already in your price, and tracking is emailed when it leaves.

The one thing that holds an order upworth reading

An order pauses if something is still outstanding on your side — an intake form you have not finished, ID verification, or lab work. It is the most common reason an order goes quiet, and the system cannot always alert you when it happens.

So if it has been quiet for a couple of days, check your email and your patient portal before anything else. That is nearly always where the missing piece is, and clearing it starts your order moving again immediately. Full checklist here.

Ordering on a Friday or at the weekend

Orders are processed seven days a week. What is not covered at weekends is anything needing a person — a stuck form, an ID check, a question for your provider. Order late on a Friday and you will likely hear more at the start of the week.

How to check where you are

Your patient portal shows the live stage of your order. If your purchase appears there and you have the confirmation email, you are in the queue and nothing is wrong.

These are typical ranges, not guarantees, and delays do happen. Something look wrong? Email info@optml.health and a person will pick it up. For anything clinical, message your physician in the portal. For emergencies, call 911.

Tirzepatide FAQs

Tirzepatide activates two receptors (GIP and GLP-1) while semaglutide activates GLP-1 alone. The literature describes the dual mechanism as having a stronger appetite-modulation profile in some populations. Whether either is appropriate for you is determined by a U.S. licensed physician.

Common (>10%): mild nausea (especially first 1-2 weeks of each new dose), decreased appetite, fatigue, constipation. Most resolve within 2-4 weeks; slower titration helps.

Less common (1-10%): diarrhea or vomiting, headache, dizziness, acid reflux, mild injection-site reaction. Tell your provider — dose adjustments usually fix these.

Rare (<1%): pancreatitis, gallbladder issues, severe allergic reaction, diabetic retinopathy worsening (in patients with diabetes).

Black-box / contraindicated: personal/family history of medullary thyroid carcinoma (MTC), MEN-2 syndrome, pregnancy, breastfeeding, severe gastroparesis.

Call your provider right away for severe stomach pain, signs of allergic reaction, vision changes, or pancreatitis-like pain. Full GLP-1 eligibility & contraindications →

OPTML's compounded tirzepatide is prepared by FDA-registered 503A pharmacies under USP <797> sterility standards, on prescription by a U.S. licensed physician. Compounded medications are not FDA-approved.

Yes. Many patients switch for stronger results or fewer GI side effects. Your OPTML provider will manage the transition and titration plan.

Not always required, but strongly recommended. We offer an optional comprehensive metabolic panel to establish baseline markers before starting treatment.

Insulated, temperature-controlled, plain packaging. Free discreet shipping. Vials are stable refrigerated; full storage instructions ship with each kit.

Flat $349/mo all-inclusive — medication, provider oversight, syringes, supplies, and shipping. Same price at every dose tier. Cancel anytime.

Compounded tirzepatide,
prescribed online.

Tirzepatide — the dual-pathway molecule, prescribed and delivered.

You were never the problem.
Your biology was.

The most studied molecule in the GLP-1 class.

Everything in your tirzepatide kit