Is semaglutide more effective than semaglutide?

Tirzepatide activates two receptors (GIP and GLP-1), while semaglutide activates GLP-1 alone. The literature describes the dual mechanism as having a stronger appetite-modulation profile in some populations.

What are the side effects?

Most common: nausea, constipation, diarrhea, fatigue, typically mild and temporary. Side effect profile is similar to semaglutide. Your provider starts you at a low dose and titrates up slowly.

How is compounded semaglutide prepared?

Compounded semaglutide is prepared by FDA-registered 503A pharmacies under USP sterility standards, on prescription by a U.S. licensed physician. Compounded medications are not FDA-approved.

Can I switch from semaglutide to semaglutide?

Yes. Many patients switch for stronger results or fewer GI side effects. Your OPTML provider will manage the transition and titration plan.

The original GLP-1 receptor agonist

Semaglutide — the original GLP-1, prescribed and delivered.

Semaglutide is a GLP-1 receptor agonist used in physician-supervised weight-management protocols. It mimics a gut hormone that reduces appetite and slows gastric emptying. OPTML dispenses compounded semaglutide on prescription by U.S. licensed physicians; compounded medications are not FDA-approved.

All-inclusive pricing — no membership fees
503A licensed pharmacies (USP <797>)
Free 2-3 day discreet shipping · cancel anytime
Only at OPTML
GLP-1 Muscle Loss Protocol included
Educational guide on muscle preservation during physician-supervised GLP-1 protocols.

Get started How it works →

Includes a consultation with a U.S.-licensed physician

Compounded medication is not FDA-approved. Starting at $249/mo · HSA/FSA eligible.

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Prescription only Prescribed by U.S.-licensed physicians

Weight Loss · GLP-1 receptor agonist

Prescribed by U.S.-licensed physicians

Semaglutide — the original GLP-1, prescribed and delivered.

✓ Licensed US providers✓ 2-3 day discreet shipping✓ Cancel anytime

LegitScript CertifiedHealthcare Merchant

Semaglutide is a GLP-1 receptor agonist used in physician-supervised weight-management protocols — it acts on the GLP-1 receptor to reduce hunger signaling and slow gastric emptying. OPTML dispenses compounded semaglutide on prescription by U.S. licensed physicians; compounded medications are not FDA-approved.

All-inclusive pricing — no membership fees
503A licensed pharmacies (USP <797> standards)
U.S.-licensed providers
Cancel anytime, no contract
Discreet 2–3 day shipping

Only at OPTML

GLP-1 Muscle Loss Protocol included

Educational guide on muscle preservation during physician-supervised GLP-1 protocols.

Get started How it works

Starting at $249/mo · Free provider consult · HSA/FSA eligible

The Rebound Cycle

80%

Roughly 8 in 10 people who lose weight through dieting alone regain it. Not because they quit. Because their biology fought back.

Wing & Phelan, Am J Clin Nutr 2005 · Sumithran et al., NEJM 2011 · Fothergill et al., Obesity 2016

How many times have you lost 10+ lbs?

Current weight 220lbs

Goal weight 180lbs

Weight you may have lost and regained

100lbs

2.5 cycles × 40 lb gap

The work was real every single time. But the body fights to keep weight on, and that pushback is biology, not a lack of discipline.

You were never the problem.
Your biology was.

And biology is something a U.S. licensed physician can measure and treat. They review your history, run your labs, and determine whether prescription treatment is appropriate for you.

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Where these numbers come from

Long-term studies of dieting consistently find most lost weight is regained within 3 to 5 years (Wing & Phelan, Am J Clin Nutr 2005). After weight loss, ghrelin rises and leptin falls, and these shifts persist for at least a year (Sumithran et al., NEJM 2011). Resting metabolic rate can stay suppressed for years (Fothergill et al., Obesity 2016). Figures describe research populations and dieting in general; they are educational, not a prediction of your results or a claim about any treatment.

Semaglutide, explained

The most-studied GLP-1 in the world.

Semaglutide is a once-weekly injectable GLP-1 receptor agonist that mimics a hormone your body already produces — slowing gastric emptying, reducing appetite, and improving insulin sensitivity. It is used in physician-supervised weight-management protocols.

The same molecule can also be prepared by licensed 503A compounding pharmacies as a personalized prescription. OPTML’s compounded semaglutide is prescribed by U.S.-licensed providers under USP <797> sterility standards, then shipped to your door monthly. Compounded preparations are not FDA-approved or evaluated by FDA for safety, effectiveness, or quality.

Semaglutide activates one receptor: GLP-1. Tirzepatide activates two: GIP and GLP-1. Semaglutide is often described as a gentler starting point, with more long-term safety data, and works well for patients who don’t need maximum titration.

The literature describes tirzepatide's dual mechanism as having a stronger appetite-modulation profile in some populations. Semaglutide is often described as a gentler starting point. Whether either is appropriate for you is determined by a U.S. licensed physician.

What you get

Everything in your semaglutide kit

No surprises, no upsells. Each shipment includes everything you need to administer safely at home, plus full clinical support.

Compounded semaglutide

Sterile, multi-dose vials. Personalized and titrated by your provider.

Sterile syringes & needles

Pre-paired insulin syringes sized for subcutaneous injection.

Alcohol pads + sharps bin

Everything for safe, sanitary self-administration at home.

Provider + care messaging

U.S.-licensed provider review and ongoing clinical support.

Discreet 2-3 day shipping

Insulated, temperature-controlled, plain packaging. Always free.

Customer reviewing her OPTML protocol on her phone

How it works

Start semaglutide in 4 simple steps.

Online assessment to first shipment in under a week. No in-person visits, no waiting rooms.

Get started →

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.

Provider evaluation

A U.S.-licensed provider reviews your intake and prescribes the right protocol, if appropriate.

Personalized plan

Compounded semaglutide, syringes, and supplies arrive in 2–3 days. Titration tailored to you.

Ongoing support

Message your provider anytime. Dose adjustments, refills, and questions handled in-app.

9:41

Question 1 of 12

What do you want to accomplish with OPTML?

Lose weight
Energy & vitality
Optimize hormones
Improve sleep & recovery

Start losing weight in 4 simple steps

Start your online visit

Answer a few questions about your health and goals, all online—no in-person doctor's office visit necessary.
Provider evaluation
Personalized plan
Ongoing support

Get started →

No commitment. No insurance needed. See full eligibility & contraindications →

Transparent pricing. No surprises.

Provider consult, compounded medication, syringes, and ongoing clinical support, all included.

Physician-directed care

A U.S.-licensed physician personally reviews every order before anything is prescribed.

U.S.-licensed physicians
Reviews every order
LegitScript Certified
503A pharmacy · USP <797>

Compounded semaglutide

One flat price.
Every dose.

One price from your first month through your full plan. No tier upgrades, no surcharges as you progress, no surprise bills.

Compounded semaglutide vial
Ongoing clinical support
Sterile syringes & alcohol prep pads
Free 2-3 day discreet shipping
Cancel anytime · HSA/FSA eligible

From

$249 /month— cancel anytime

Same price at every step of your plan.

Get started →

Your licensed physician personalizes your plan to your response — your monthly price stays exactly the same.

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

Monthly

$249/month— cancel anytime

Billed monthly. Cancel anytime.

Compounded semaglutide
Provider consultation
Syringes & supplies
Free 2-3 day shipping
Ongoing support

Start at $249/mo

Semaglutide FAQs

OPTML's compounded semaglutide is prepared by FDA-registered 503A pharmacies under USP <797> sterility standards, on prescription by a U.S. licensed physician. Compounded medications are not FDA-approved.

Semaglutide activates one receptor (GLP-1). Tirzepatide activates two (GIP + GLP-1). The literature describes the dual mechanism as having a stronger appetite-modulation profile in some populations; semaglutide is often described as a gentler starting point. Whether either is appropriate for you is determined by a U.S. licensed physician.

Common (>10%): mild nausea (especially first 1-2 weeks of each new dose), decreased appetite, fatigue, constipation. Most resolve within 2-4 weeks; slower titration helps.

Less common (1-10%): diarrhea or vomiting, headache, dizziness, acid reflux, mild injection-site reaction. Tell your provider — dose adjustments usually fix these.

Rare (<1%): pancreatitis, gallbladder issues, severe allergic reaction, diabetic retinopathy worsening (in patients with diabetes).

Black-box / contraindicated: personal/family history of medullary thyroid carcinoma (MTC), MEN-2 syndrome, pregnancy, breastfeeding, severe gastroparesis.

Call your provider right away for severe stomach pain, signs of allergic reaction, vision changes, or pancreatitis-like pain. Full GLP-1 eligibility & contraindications →

Yes. Many patients start on semaglutide for the gentler ramp, then move to tirzepatide for stronger results once they're past the initial titration. Your OPTML provider manages the transition and titration plan.

Not always required, but strongly recommended. We offer an optional comprehensive metabolic panel to establish baseline markers before starting treatment.

Insulated, temperature-controlled, plain packaging. Free 2-3 day discreet shipping. Vials are stable refrigerated; full storage instructions ship with each kit.

Flat $249/mo all-inclusive — medication, provider oversight, syringes, supplies, and shipping. Same retail at every dose tier. Cancel anytime.

Weight-loss medication disclaimer. OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.

Semaglutide — the original GLP-1, prescribed and delivered.

Semaglutide — the original GLP-1, prescribed and delivered.

You were never the problem.
Your biology was.

The most-studied GLP-1 in the world.

Everything in your semaglutide kit