HOMA-IR
A calculated estimate of insulin resistance from fasting glucose and fasting insulin.
What is it
HOMA-IR is a calculated index of insulin resistance derived from fasting glucose and fasting insulin values. It provides a single-number snapshot of metabolic insulin sensitivity.
Why it's measured
HOMA-IR has been used in research as a non-invasive estimate of insulin resistance and has been associated with cardiometabolic risk.
Reference range
Standard laboratory reference
< 1.5 index
Reference ranges vary by laboratory. Your individual reference range will appear on your test report and should be interpreted by your physician in the context of your overall health profile.
What results may indicate
Elevated
Has been associated with insulin resistance and cardiometabolic risk in published research.
Lower
Is generally considered favorable.
These associations are general. They are not a personal diagnosis or prediction. Discuss your individual results with your physician in the context of your full health profile.
When it's measured
Calculated from fasting glucose + fasting insulin — reported when both are measured.
Related markers
Common questions
HOMA-IR is a calculated index of insulin resistance derived from fasting glucose and fasting insulin values. It provides a single-number snapshot of metabolic insulin sensitivity.
It's one of the markers used to build a fuller picture of your health. On its own it tells you very little, so it's most informative when reviewed alongside related markers.
It's measured from a standard blood draw at Quest or LabCorp. HOMA-IR (calculated) is one of the markers included in the OPTML Apex Panel, where your results are read across systems and reviewed by a U.S.-licensed physician.
Reference ranges vary by laboratory, and a single value rarely tells the whole story. Review your result with a physician in the context of your other markers, symptoms, and history.
HOMA-IR (calculated) is one signal among many. Answer a few quick questions and we’ll point you to the panel that fits.
HOMA-IR is calculated from fasting glucose and fasting insulin, both of which respond to training. Because it is driven largely by the insulin term, it tends to improve with consistent resistance training earlier than glucose alone would suggest. If you want a structured place to start, the training library lists every programme we publish by days per week and equipment.
Measured in
A complete look at your heart, hormones, metabolism, inflammation, and longevity systems — drawn at Quest or LabCorp, reviewed by a U.S.-licensed physician.
Find the right panel →This information is for general educational purposes only and is not medical advice. Lab results alone are not intended to diagnose, treat, or cure any condition and do not replace the advice of a healthcare provider. OPTML does not offer medical advice, a diagnosis, medical treatment, or any form of medical opinion.
OPTML offers compounded semaglutide and tirzepatide, prescribed and overseen by U.S.-licensed physicians. Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. OPTML is not associated with, endorsed by, or affiliated with the manufacturers of FDA-approved branded weight-loss medications, and does not sell or supply those branded products. Anyone interested in an FDA-approved branded medication should consult a licensed healthcare provider or pharmacist. Individual results vary; no specific result is promised, and weight management requires ongoing medical guidance.
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