Hormones system

IGFBP-3

The main carrier protein for IGF-1 — used alongside IGF-1 in evaluation.

What is it

IGFBP-3 — in plain English.

Insulin-like growth factor binding protein 3 is the primary carrier protein for IGF-1 in circulation. It is used alongside IGF-1 to evaluate the GH-IGF axis.

Why it's measured

What IGFBP-3 can reveal.

IGFBP-3 has been used in clinical evaluation of GH disorders and is studied in research on metabolic health and aging.

Reference range

Where most laboratories draw the standard line.

Standard laboratory reference

Age-dependent mg/L

Reference ranges vary by laboratory. Your individual reference range will appear on your test report and should be interpreted by your physician in the context of your overall health profile.

What results may indicate

Higher vs. lower IGFBP-3 — at a high level.

Elevated

Often parallels IGF-1 elevation in research literature.

Lower

Has been associated with GH deficiency in research literature.

These associations are general. They are not a personal diagnosis or prediction. Discuss your individual results with your physician in the context of your full health profile.

When it's measured

When IGFBP-3 is typically run.

Measured alongside IGF-1 in GH-axis evaluation.

Related markers

Often measured alongside IGFBP-3.

Measured in

IGFBP-3 is one of 160 biomarkers in the Apex Panel.

A complete look at your heart, hormones, metabolism, inflammation, and longevity systems — drawn at Quest or LabCorp, reviewed by a U.S.-licensed physician.

Explore the Apex Panel
160 biomarkers13 body systemsPhysician-reviewed
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This information is for general educational purposes only and is not medical advice. Lab results alone are not intended to diagnose, treat, or cure any condition and do not replace the advice of a healthcare provider. OPTML does not offer medical advice, a diagnosis, medical treatment, or any form of medical opinion.