Liver system

FIB-4 Score (calculated)

FIB-4

A calculated score estimating liver fibrosis risk from routine labs.

What is it

FIB-4 Score (calculated) — in plain English.

The FIB-4 score is calculated from age, AST, ALT, and platelet count. It has been validated in research as a non-invasive estimate of liver fibrosis risk.

Why it's measured

What FIB-4 can reveal.

FIB-4 has been studied as a screening tool for advanced liver fibrosis, particularly in fatty liver disease.

Reference range

Where most laboratories draw the standard line.

Standard laboratory reference

< 1.3 score

Reference ranges vary by laboratory. Your individual reference range will appear on your test report and should be interpreted by your physician in the context of your overall health profile.

What results may indicate

Higher vs. lower FIB-4 — at a high level.

Elevated

Higher values have been associated with elevated liver fibrosis risk in research literature.

Lower

Is generally considered favorable.

These associations are general. They are not a personal diagnosis or prediction. Discuss your individual results with your physician in the context of your full health profile.

When it's measured

When FIB-4 is typically run.

Calculated automatically from routine lab values when ordered.

Related markers

Often measured alongside FIB-4.

Measured in

FIB-4 is one of 160 biomarkers in the Apex Panel.

A complete look at your heart, hormones, metabolism, inflammation, and longevity systems — drawn at Quest or LabCorp, reviewed by a U.S.-licensed physician.

Explore the Apex Panel
160 biomarkers13 body systemsPhysician-reviewed
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This information is for general educational purposes only and is not medical advice. Lab results alone are not intended to diagnose, treat, or cure any condition and do not replace the advice of a healthcare provider. OPTML does not offer medical advice, a diagnosis, medical treatment, or any form of medical opinion.