Metals system

Zinc Protoporphyrin

ZPP

A marker that rises with chronic lead exposure or iron deficiency.

What is it

Zinc Protoporphyrin — in plain English.

Zinc protoporphyrin is a heme precursor that accumulates when iron is unavailable or when lead interferes with heme synthesis. It is used as a marker of chronic lead exposure and iron deficiency.

Why it's measured

What ZPP can reveal.

Elevated ZPP has been associated with chronic lead exposure and iron deficiency in research literature.

Reference range

Where most laboratories draw the standard line.

Standard laboratory reference

< 35 μg/dL

Reference ranges vary by laboratory. Your individual reference range will appear on your test report and should be interpreted by your physician in the context of your overall health profile.

What results may indicate

Higher vs. lower ZPP — at a high level.

Elevated

Has been associated with chronic lead exposure or iron deficiency in research literature.

Lower

Generally considered favorable.

These associations are general. They are not a personal diagnosis or prediction. Discuss your individual results with your physician in the context of your full health profile.

When it's measured

When ZPP is typically run.

Used in lead exposure screening and iron deficiency evaluation.

Related markers

Often measured alongside ZPP.

Measured in

ZPP is one of 160 biomarkers in the Apex Panel.

A complete look at your heart, hormones, metabolism, inflammation, and longevity systems — drawn at Quest or LabCorp, reviewed by a U.S.-licensed physician.

Explore the Apex Panel
160 biomarkers13 body systemsPhysician-reviewed
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This information is for general educational purposes only and is not medical advice. Lab results alone are not intended to diagnose, treat, or cure any condition and do not replace the advice of a healthcare provider. OPTML does not offer medical advice, a diagnosis, medical treatment, or any form of medical opinion.