OPTML for Women · Progesterone

Progesterone, restored.

The molecule your body produced before perimenopause, bioidentical, micronized, taken at bedtime. Restores deeper sleep, calmer mood, and protects the endometrium alongside estradiol. $79/mo, all-inclusive.

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  • Bioidentical micronized progesterone
  • 100mg or 200mg
  • Bedtime oral capsule
  • Provider-titrated
Start at $79/mo See full HRT page
Bioidentical micronized progesterone capsule, OPTML Micronized progesterone · bedtime

What progesterone actually does

01

Deeper sleep

Oral progesterone metabolizes to allopregnanolone, a GABA-A modulator. Patients describe noticeably deeper, more restorative sleep within 1-2 weeks.

02

Calmer mood

The same GABAergic effect lifts anxiety and stabilizes mood, particularly through perimenopause and the luteal phase.

03

Endometrial protection

If you take estradiol and have an intact uterus, progesterone protects the endometrium from unopposed estrogen exposure. Critical for safe HRT.

04

Perimenopause balance

Progesterone often drops before estrogen during perimenopause. Restoring it can ease luteal-phase symptoms even before menopause.

Bioidentical · micronized Micronized progesterone capsule dissolving

The molecule, not a substitute.

Synthetic progestins (like medroxyprogesterone) are not progesterone, they bind the receptor differently and carry the cardiovascular and breast-tissue concerns that drove the original WHI headlines. Micronized progesterone is the molecule your body produced. Same structure. Same metabolite (allopregnanolone) that drops you into deeper sleep. That difference is the point.

Taken at bedtime, oral micronized progesterone restores sleep architecture, eases anxiety, and, alongside estradiol, protects the endometrium. Provider-titrated 100mg or 200mg.

Transparent pricing

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Retail · All-inclusive
Progesterone (100mg or 200mg)
$79/month— cancel anytime

Billed monthly. Cancel anytime.

  • Bioidentical micronized progesterone
  • Bedtime oral capsule
  • Provider-titrated
  • Free 2-3 day shipping
Start at $79/mo

Your monthly price includes everything.

Physician consultation, prescription, and ongoing medical oversight. No hidden fees. No separate membership. Just your optml protocol.

What to expect, week by week

Most patients describe a quiet, steady restoration, not a jolt. Here's the typical arc.

Week 1

Sleep deepens

The allopregnanolone metabolite hits GABA-A receptors within hours. Most patients notice longer, less interrupted sleep on night 2-5.

Weeks 2-3

Mood evens out

Anxiety baseline drops. Luteal-phase irritability and racing thoughts soften. Less reactive, more like yourself.

Weeks 4-6

Cycle calms

For perimenopausal patients: less spotting, more predictable cycles. Breast tenderness and bloating ease.

Ongoing

Endometrial protection

If you take estradiol, progesterone is the safety partner that keeps the endometrium healthy long-term.

Real patients, real results

Women using bioidentical micronized progesterone through OPTML, for sleep, mood, and HRT protection.

Names changed for privacy. Individual results vary.

Prescribed by board-certified U.S.-licensed clinicians

Licensed in all 50 states · Meet your care team

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Progesterone FAQ

What does progesterone do?

Improves sleep (via the allopregnanolone metabolite, a GABA-modulator), reduces anxiety, supports mood through perimenopause, and, when paired with estradiol, protects the endometrium from unopposed estrogen.

100mg vs 200mg?

100mg is a typical starting dose for sleep/mood and for endometrial protection on cyclic estrogen. 200mg is more common for continuous-combined HRT or stronger sleep needs. Provider titrates.

Do I need progesterone if I'm on estradiol?

If you have an intact uterus: yes. Unopposed estrogen raises endometrial cancer risk; progesterone protects the endometrium. After hysterectomy: not required for endometrial protection, though many patients still benefit for sleep and mood.

Bioidentical micronized vs synthetic progestins?

Current evidence favors bioidentical micronized progesterone over synthetic progestins (medroxyprogesterone) for cardiovascular and breast safety. The 2002 WHI risk concerns were largely tied to synthetic progestin use, not bioidentical progesterone.

Why bedtime?

Oral progesterone is sedating. Bedtime dosing harnesses the sleep-supportive effect rather than fighting it during the day.

Progesterone Starting at$79/mo
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