Thyroid system

Reverse T3

rT3

An inactive form of T3 — can be elevated during illness or stress.

What is it

Reverse T3 — in plain English.

Reverse T3 is an isomer of T3 that does not activate thyroid receptors. Its production rises during severe illness, caloric restriction, and certain stress states.

Why it's measured

What rT3 can reveal.

Reverse T3 has been studied in research on non-thyroidal illness syndrome and the body's response to physiologic stress.

Reference range

Where most laboratories draw the standard line.

Standard laboratory reference

9 – 24 ng/dL

Reference ranges vary by laboratory. Your individual reference range will appear on your test report and should be interpreted by your physician in the context of your overall health profile.

What results may indicate

Higher vs. lower rT3 — at a high level.

Elevated

Has been associated with severe illness, caloric restriction, and stress states in research literature.

Lower

Is generally not clinically concerning in isolation.

These associations are general. They are not a personal diagnosis or prediction. Discuss your individual results with your physician in the context of your full health profile.

When it's measured

When rT3 is typically run.

Used in specialized thyroid evaluation, particularly when symptoms persist despite normal standard thyroid markers.

Related markers

Often measured alongside rT3.

Measured in

rT3 is one of 160 biomarkers in the Apex Panel.

A complete look at your heart, hormones, metabolism, inflammation, and longevity systems — drawn at Quest or LabCorp, reviewed by a U.S.-licensed physician.

Explore the Apex Panel
160 biomarkers13 body systemsPhysician-reviewed
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This information is for general educational purposes only and is not medical advice. Lab results alone are not intended to diagnose, treat, or cure any condition and do not replace the advice of a healthcare provider. OPTML does not offer medical advice, a diagnosis, medical treatment, or any form of medical opinion.