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Factual, peer-reviewed references on the treatments offered through OPTML. Written and maintained by our clinical team. Use these pages for a quick, citation-backed understanding before you consult with a physician.

What Is Semaglutide?

GLP-1 receptor agonist. Mechanism, dosing, STEP-1 and SELECT trial data.

What Is Tirzepatide?

Dual GIP/GLP-1 agonist. Mechanism, SURMOUNT-1 outcomes, comparison to semaglutide.

What Is TRT?

Testosterone replacement therapy. Forms, monitoring, TRAVERSE safety data.

What Is NAD+?

Nicotinamide adenine dinucleotide. Biology, decline with age, therapy formats.

What Is Enclomiphene?

SERM that raises natural testosterone while preserving fertility.

What Is HRT?

Hormone replacement therapy for women. WHI re-analysis, KEEPS, ELITE timing data.

What Is Estradiol?

Bioidentical 17β-estradiol. Forms, routes, oral vs. transdermal VTE risk.

What Is Progesterone?

Bioidentical micronized progesterone. Endometrial protection, sleep, GABA effects.

What Is Microdose GLP-1?

Sub-clinical semaglutide and tirzepatide for metabolic optimization, not weight loss.

What Is Sermorelin?

GHRH analog. Pituitary-mediated GH release, sleep, body composition.