Comparison · Updated April 2026

OPTML vs. Hims: not the same kind of telehealth.

Hims is built for the cheapest possible mainstream Rx. OPTML is built for physician-led, lab-driven optimization, GLP-1s, TRT, NAD+, enclomiphene, and longevity protocols Hims doesn't carry. The right answer depends on what you're actually trying to solve.

5 treatments OPTML carries that Hims doesn't Physician-led, not NP-gated Labs available at member rates

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Head-to-head at a glance

Everything you'd want to know, in one table.

Feature	OPTML	Hims
NAD+ therapy	✓ Subcutaneous injections, $179/mo or $489 / 3 months	✗ Not offered
Enclomiphene (fertility-preserving T)	✓ $129/mo, preserves fertility, no injections	✗ Not offered
Compounded Tirzepatide (the strongest GLP-1)	✓ $349/mo, full availability, all titration doses	✗ Limited availability
Comprehensive blood panel + 90-day follow-up labs	✓ Included in most plans	✗ Add-on, limited markers, no included follow-up
Physician-led care (not NP/PA-gated)	✓ U.S.-licensed physician supervision on every plan	✗ Primarily NP / PA driven
Longevity protocols (peptides, NAD+, advanced testing)	✓ Core focus	✗ Mass-market focus
Testosterone Replacement Therapy (TRT)	✓ $199/mo annual, physician-led, labs and dose tuning included	Offered, but limited lab inclusion and oversight depth
Compounded Semaglutide	✓ $249/mo, bundled with physician oversight, labs, and 90-day follow-up	$199/mo, medication only
Bioidentical HRT for women (estradiol + progesterone)	✓ Starting at $199/mo, see HRT page →	✗ Not offered
Microdose GLP-1 (sub-clinical sema/tirz for optimization)	✓ Sema $199/mo · Tirz $299/mo, see microdose page →	✗ Not offered
Sermorelin (GHRH peptide for sleep, recovery, body comp)	✓ $189/mo, see sermorelin page →	✗ Not offered
True 12-month cost (med + provider + labs)	✓ ~$2,388 all-in (annual plan)	✗ ~$2,388 medication + ~$300-600 add-on labs = $2,688-2,988
Unlimited messaging with care team	✓ 24-hour response time	✓ Included
HSA / FSA eligible	✓ Yes	✓ Yes

When labs and physician oversight are included, OPTML is typically cheaper or equal over a 12-month protocol, and unlocks treatments Hims doesn't carry at all.

Where each platform actually wins

The short version for anyone comparison-shopping.

optml, pick this if

You want tirzepatide (the strongest GLP-1) reliably available
You're 35+ and want physician-led, lab-driven care
You care about preserving fertility on a low-T protocol (enclomiphene)
You're optimizing more than one system, weight, hormones, longevity
You want labs and 90-day follow-up included, not bolted on
NAD+ or peptides are part of your plan

Hims, pick this if

You only need basic semaglutide at the lowest sticker price
You don't want labs or follow-up included
You're comfortable with NP/PA-only care
You don't need tirzepatide, NAD+, enclomiphene, or longevity protocols

Bottom line

For most adults serious about GLP-1, hormone, or longevity care, OPTML wins. Hims wins narrowly on basic-semaglutide-only sticker price, but loses on physician oversight, treatment breadth, and 12-month bundled value.

Frequently asked questions

No. Both are $249/mo for compounded semaglutide as a sticker price, but Hims sells medication-only at that price, while OPTML's $249 includes physician (not NP) oversight, baseline labs, 90-day follow-up labs, and dose tuning. The all-in 12-month cost gap heavily favors OPTML. For tirzepatide, NAD+, sermorelin, HRT, and enclomiphene, Hims has no equivalent at any price.

OPTML protocols are led by U.S.-licensed physicians with NP and PA support, important when your case involves labs, dose calibration, or multi-system care. Hims is primarily NP/PA-driven. For straightforward GLP-1 prescriptions either model works; for hormone work, complex cases, or longevity protocols, physician oversight makes a real difference.

A lot. NAD+ subcutaneous injections, enclomiphene (the fertility-preserving alternative to TRT), reliable tirzepatide availability across all titration doses, comprehensive lab panels included on most plans, 90-day follow-up labs, and a full longevity-protocol suite. Hims is built for mainstream Rx volume; OPTML is built for optimization.

Yes, and it's common. Share your prior labs and current dose during intake; your OPTML provider picks up where you left off, usually with a shorter onboarding. If you're switching for tirzepatide or to add NAD+/enclomiphene, the transition is straightforward.

OPTML vs. Hims: not the same kind of telehealth.

Head-to-head at a glance

Where each platform actually wins

Frequently asked questions

Compare pricing for your own plan